Opioid poorly-responsive cancer pain. Part 1: Clinical considerations

被引：83

作者：

Mercadante, S

Portenoy, RK

机构：

[1] La Maddalena Canc Ctr, Anesthes & Intens Care & Pain Relief & Palliat Ca, I-90146 Palermo, Italy

[2] Soc Assistenza Malato Oncol Terminale, Home Palliat Care Program, Palermo, Italy

[3] Beth Israel Med Ctr, Dept Pain Med & Palliat Care, New York, NY 10003 USA

来源：

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT | 2001年 / 21卷 / 02期

关键词：

cancer pain; opioid responsiveness; tolerance; neuropathic pain; breakthrough pain; side effects; opioid metabolites; routes of administration;

D O I：

10.1016/S0885-3924(00)00228-1

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Pain that is poorly responsive to opioid analgesics is challenging for physicians who deal with cancer patients. Numerous factors may influence analgesic response during the course of the illness. These include changing nociception associated with disease progression, the appearance of intractable side effects, the development of tolerance, the presence of neuropathic pain, the temporal pattern, the effects produced by the production of opioid metabolites, and many others. These factors influence the delicate balance between pain relief and opioid toxicity that must be achieved in cancer patients with pain. (C) U.S. Cancer Pain Relief Committee, 2001.

引用

页码：144 / 150

页数：7

共 58 条

[1] LACK OF ANALGESIC EFFECT OF OPIOIDS ON NEUROPATHIC AND IDIOPATHIC FORMS OF PAIN [J].