Preservation solutions for attenuation of ischemia-reperfusion injury in vascularized composite allotransplantation

被引：7

作者：

Datta, Shaishav ^{[1
,2
]}

Fitzpatrick, Aisling M. ^{[1
,3
]}

Haykal, Siba ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Temerty Fac Med, 200 Elizabeth St 8N-869, Toronto, ON M5G 2C4, Canada

[2] Univ Toronto, Toronto Gen Hosp, Univ Hlth Network, Latner Thorac Surg Labs, Toronto, ON, Canada

[3] Univ Toronto, Dept Surg, Div Plast & Reconstruct Surg, Toronto, ON, Canada

来源：

SAGE OPEN MEDICINE | 2021年 / 9卷

关键词：

Vascularized composite allotransplantation; ischemia-reperfusion injury; preservation solution; UNIVERSITY-OF-WISCONSIN; MITOCHONDRIAL PERMEABILITY TRANSITION; EX-SITU PERFUSION; SKELETAL-MUSCLE; ISCHEMIA/REPERFUSION INJURY; TISSUE ALLOTRANSPLANTATION; ORGAN PRESERVATION; COLD-STORAGE; KIDNEY-PRESERVATION; SIGNALING PATHWAYS;

D O I：

10.1177/20503121211034924

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vascularized composite allotransplantation represents the final level of the reconstructive ladder, offering treatment options for severe tissue loss and functional deficiencies. Vascularized composite allotransplantation is particularly susceptible to ischemia-reperfusion injury and requires preservation techniques when subjected to extended storage times prior to transplantation. While static cold storage functions to reduce ischemic damage and is widely employed in clinical settings, there exists no consensus on the ideal preservation solution for vascularized composite allotransplantation. This review aims to highlight current clinical and experimental advances in preservation solution development and their critical role in attenuating ischemia-reperfusion injury in the context of vascularized composite allotransplantation.

引用

页数：13

共 114 条

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