Alternative splicing in cancer: implications for biology and therapy

被引：199

作者：

Chen, J. ^{[1
,2
]}

Weiss, W. A. ^{[2
,3
]}

机构：

[1] Univ Calif San Francisco, Biomed Sci Grad Program, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Neurol Surg & Pediat, San Francisco, CA 94158 USA

来源：

ONCOGENE | 2015年 / 34卷 / 01期

关键词：

alternative splicing; aberrant splicing; p53; BARD1; AR; HUMAN ANDROGEN RECEPTOR; WILD-TYPE P53; PRE-MESSENGER-RNA; DOMAIN BARD1 GENE; TUMOR-SUPPRESSOR; PYRUVATE-KINASE; SOLUBLE-FAS; IN-VIVO; TRANSCRIPTIONAL ACTIVATION; CELL SENESCENCE;

D O I：

10.1038/onc.2013.570

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative splicing has critical roles in normal development and can promote growth and survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific mRNA transcripts, can lead to loss-of-function in tumor suppressors or activation of oncogenes and cancer pathways. Emerging data suggest that aberrant splicing products and loss of canonically spliced variants correlate with stage and progression in malignancy. Here, we review the splicing landscape of TP53, BARD1 and AR to illuminate roles for alternative splicing in cancer. We also examine the intersection between alternative splicing pathways and novel therapeutic approaches.

引用

页码：1 / 14

页数：14

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