Preparation of 99Mo/99mTc generator based on cross-linked chitosan polymer using low-specific activity (n,γ)99Mo

The cross-linked chitosan polymer (CCM) is an emerging adsorbent matrix. The CCM matrix has very high adsorption for Mo and thus can be utilized to prepare Mo-99/Tc-99m generator using low-specific activity (n, gamma) Mo-99. The elution efficiency of Tc-99m from Mo-99/Tc-99m generator based on the CCM polymer oxidized and non-oxidized form has been found more than 75% and about 40%, respectively. The Na[Tc-99m]TcO4 eluates obtained were clear solutions with pH 5-6 and the R C Purities of 99%. The Mo-99 breakthrough in the Tc-99m fraction with alumina guard column (0.5 g) was 0.002 +/- 0.003 (n = 9). The radionuclidic purity of (TcO4)-Tc-99m (-) was more than 99.99%. The Al and Mo content in the eluted Tc-99m was less than 10 A mu g/ml. The R C Purity of the labeled compounds was greater than 95%.