Antioxidant and Cytoprotective Activity of Oxydiacetate Complexes of Cobalt(II) and Nickel(II) with 1,10-Phenantroline and 2,2'-Bipyridine

被引：11
|
作者：
Piotrowska-Kirschling, Agnieszka [1 ]
Drzezdzon, Joanna [1 ]
Kloska, Anna [2 ]
Wyrzykowski, Dariusz [1 ]
Chmurzynski, Lech [1 ]
Jacewicz, Dagmara [1 ]
机构：
[1] Univ Gdansk, Fac Chem, Wita Stwosza 63, PL-80308 Gdansk, Poland
[2] Univ Gdansk, Fac Biol, Wita Stwosza 59, PL-80308 Gdansk, Poland
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2018年 / 185卷 / 01期
关键词：
Cobalt(II) and nickel(II) complexes; Cytoprotective activity; Fibroblasts; Oxydiacetate ion; Oxidative stress; LIGAND; OXOVANADIUM(IV); ANIONS; OXYGEN;
D O I：
10.1007/s12011-018-1243-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The antioxidant properties of oxydiacetate complexes of cobalt(II) and nickel(II) with 1,10-phenantroline and 2,2'-bipyridine have been investigated towards the superoxide radical using the nitro blue tetrazolium chloride (NBT) test and the cyclic voltammetry (CV). Moreover, the biological activity of the complexes under study has been investigated in the Human Dermal Fibroblasts adult (HDFa) cell line. In the first step, the cytotoxic and the antiproliferative activities of the complexes were examined. Subsequently, the cytoprotective properties of the complexes have been investigated in an oxidative stress conditions induced by H2O2.
引用
收藏
页码：244 / 251
页数：8
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