A weak signal for strong responses:: Interferon-α/β revisited

被引：411
作者：
Taniguchi, T
Takaoka, A
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1130033, Japan
[2] Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1130033, Japan
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 05期
关键词：
D O I：
10.1038/35073080
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Biological systems have acquired adaptability and robustness against rapid environmental changes. A typical example is the immune system, which eradicates invading pathogens such as viruses, interferons alpha and beta, which are produced in response to viral infection, are essential components of this system but are also produced at low levels in the absence of infection. What is the purpose of the constitutive weak interferon-alpha/beta signal?
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页码：378 / 386
页数：9
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