Regulation of chromatin structure and gene activity by poly(ADP-ribose) polymerases

被引：51

作者：

Tulin, A ^{[1
]}

Chinenov, Y

Spradling, A

机构：

[1] Carnegie Inst Sci, HHMI Labs, Baltimore, MD 21210 USA

[2] Univ Michigan, Med Ctr, HHMI Labs, Ann Arbor, MI 48109 USA

来源：

CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 56 | 2003年 / 56卷

关键词：

D O I：

10.1016/S0070-2153(03)01007-X

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Poly(ADP-ribose) polymerase 1 (PARP1) is an abundant nuclear protein that plays an important role in repairing DNA and responding to infection. Here we review recent evidence that PARP1 and related proteins also carry out crucial functions regulating genes during normal development. Genetic studies in mammals and Drosophila have implied that PARPs mediate rapid responses to environmental stimuli, including infection, stress, hormones, and growth signals. In addition, these polymerases may control fundamental processes that differentially mold and remodel chromatin within the many cell types of a developing embryo. We discuss a unified mechanism of PARP action during DNA repair, gene transcription, and chromatin modulation. © 2003 Elsevier Inc. All rights reserved.

引用

页码：55 / +

页数：35

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