Protective role of tenuigenin on sepsis-induced acute kidney injury in mice

Acute kidney injury (AKI) is a severe complication of sepsis, which largely contributes to the associated high mortality rate. Tenuigenin (TNG) is a natural product isolated from Polygala tenuifolia root, which possesses antiinflammatory and anti-oxidant properties. The present study investigated the effects of TNG on sepsis-associated AKI in mice subjected to cecal ligation and puncture (CLP). TNG was demonstrated to alleviate sepsis-induced AKI by reducing pathological changes and significantly decreasing the levels of blood urea nitrogen, serum creatinine and kidney coefficient. The production of inflammatory cytokines, including tumor necrosis factor a and interleukin-6, was markedly inhibited by TNG. Hematoxylin-eosin staining revealed that the morphological changes of kidney tissues in CLP mice were reversed following TNG treatment. Furthermore, treatment with TNG inhibited the production of nitric oxide and prostaglandin E-2. Finally, TNG inhibited the activation of the nuclear factor-kappa B (NF-kappa B) signaling pathway. The present study suggested that TNG alleviates sepsis-induced AKI by inhibiting the NF-kappa B signaling pathway, which provides a novel approach for treating sepsis-induced AKI.