Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants

被引：89

作者：

Choi, Angela ^{[1
]}

Koch, Matthew ^{[1
]}

Wu, Kai ^{[1
]}

Dixon, Groves ^{[1
]}

Oestreicher, Judy ^{[1
]}

Legault, Holly ^{[1
]}

Stewart-Jones, Guillaume B. E. ^{[1
]}

Colpitts, Tonya ^{[1
]}

Pajon, Rolando ^{[1
]}

Bennett, Hamilton ^{[1
]}

Carfi, Andrea ^{[1
]}

Edwards, Darin K. ^{[1
]}

机构：

[1] Moderna Inc, Cambridge, MA 02139 USA

来源：

JOURNAL OF VIROLOGY | 2021年 / 95卷 / 23期

基金：

美国国家卫生研究院;

关键词：

COVID-19; SARS-CoV-2 variants of concern; mRNA-1273; neutralization;

D O I：

10.1128/JVI.01313-21

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The emergence of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) variants has led to growing concerns over increased transmissibility and the ability of some variants to partially escape immunity. Sera from participants immunized on a prime-boost schedule with the mRNA-1273 COVID-19 vaccine were tested for neutralizing activity against several SARS-CoV-2 variants, including variants of concern (VOCs) and variants of interest (VOIs), compared to neutralization of the wild-type SARS-CoV-2 virus (designated D614G). Results showed minimal, statistically nonsignificant effects on neutralization titers against the B.1.1.7 (Alpha) variant (1.2-fold reduction compared with D614G); other VOCs, such as B.1.351 (Beta, including B.1.351-v1, B.1.351-v2, and B.1.351 v3), P.1 (Gamma), and B.1.617.2 (Delta), showed significantly decreased neutralization titers ranging from 2.1-fold to 8.4-fold reductions compared with D614G, although all remained susceptible to mRNA-1273-elicited serum neutralization. IMPORTANCE In light of multiple variants of SARS-CoV-2 that have been documented globally during the COVID-19 pandemic, it remains important to continually assess the ability of currently available vaccines to confer protection against newly emerging variants. Data presented herein indicate that immunization with the mRNA-1273 COVID-19 vaccine produces neutralizing antibodies against key emerging variants tested, including variants of concern and variants of interest. While the serum neutralization elicited by mRNA-1273 against most variants tested was reduced compared with that against the wild-type virus, the level of neutralization is still expected to be protective. Such data are crucial to inform ongoing and future vaccination strategies to combat COVID-19.

引用

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