Tumor Necrosis Factor-Alpha in Very Elderly Patients with Coronary Artery Disease

被引:0
作者
Topolyanskaya, Svetlana, V [1 ]
Eliseeva, Tatyana A. [2 ]
Godovkina, Irina E. [1 ]
Vasilieva, Irina S. [1 ]
Vakulenko, Olga N. [2 ]
Dvoretski, Leonid, I [1 ]
机构
[1] First Moscow State Med Univ Sechenov Univ, Dept Hosp Therapy N2, Moscow, Russia
[2] War Vet Hosp, Moscow, Russia
来源
AGING MEDICINE AND HEALTHCARE | 2021年 / 12卷 / 04期
关键词
Tumor necrosis factor-alpha (TNF-alpha); inflammaging; coronary artery disease; elderly; centenarians; URIC-ACID; INTERLEUKIN-6; PATHOGENESIS; INFLAMMATION; TNF;
D O I
10.33879/AMH.124.2020.10036
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background/Purpose: Limited data are available on tumor necrosis factor-alpha (TNF-alpha) in elderly patients with coronary artery disease (CAD), therefore, we evaluated TNF-alpha levels and their relationships with various disorders. Methods: 130 patients were enrolled in the cross-sectional study: 102 with CAD in the study group, 28 without CAD in the control. Patient's age varied from 77 to 101 years; 56.2% of patients were over 90 years old. Serum TNF-alpha levels (N <8.1 pg/ml) were determined by enzyme-linked immunosorbent assay. Results: Mean TNF-alpha concentration was 9.2 +/- 4.7 (3.9-31.9) pg/ml. Increased TNF-alpha levels were found in 54.6% of patients. In patients with CAD mean TNF-alpha concentration reached 10.0 +/- 4.9 pg/ml, in control group was 6.1 +/- 1.8 pg/ml (p <0.001). TNF-alpha levels were higher in patients with heart failure (p=0.002). Among patients younger than 90 years, much more significant relationships between TNF-alpha levels and echocardiographic parameters were observed in comparison with patients older than 90 years. In patients with hyperuricemia mean TNF-alpha concentration was 10.9 +/- 5.3 pg/ml, in patients with normal uric acid was 7.5 +/- 2.5 pg/ml (p <0.001). In patients with CAD positive correlations were found between TNF-alpha and uric acid (r=0.45; p <0.001), creatinine (r=0.24; p=0.01), urea (r=0.38; p <0.001), negative correlations were registered between TNF-alpha and high density lipoprotein (HDL)-cholesterol levels (r=-0.42; p <0.001), but there were no significant relationships in the control group. In patients younger than 90 years old mean TNF-alpha values reached 10.5 pg/ml, in patients older than 90 years was 8.1 pg/ml (p=0.003). Conclusion: The study results demonstrated frequent TNF-alpha increase in very elderly patients with CAD. Increased TNF-alpha levels are associated with various pathology. Copyright (C) 2021, Asian Association for Frailty and Sarcopenia and Taiwan Association for Integrated Care. Published by Full Universe Integrated Marketing Limited.
引用
收藏
页码:137 / 144
页数:8
相关论文
共 26 条
  • [1] Reverse Epidemiology of Traditional Cardiovascular Risk Factors in the Geriatric Population
    Ahmadi, Seyed-Foad
    Streja, Elani
    Zahmatkesh, Golara
    Streja, Dan
    Kashyap, Moti
    Moradi, Hamid
    Molnar, Miklos Z.
    Reddy, Uttam
    Amin, Alpesh N.
    Kovesdy, Csaba P.
    Kalantar-Zadeh, Kamyar
    [J]. JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2015, 16 (11) : 933 - 939
  • [2] Inflammation and Progression of CKD: The CRIC Study
    Amdur, Richard L.
    Feldman, Harold I.
    Gupta, Jayanta
    Yang, Wei
    Kanetsky, Peter
    Shlipak, Michael
    Rahman, Mahboob
    Lash, James P.
    Townsend, Raymond R.
    Ojo, Akinlolu
    Roy-Chaudhury, Akshay
    Go, Alan S.
    Joffe, Marshall
    He, Jiang
    Balakrishnan, Vaidyanathapuram S.
    Kimmel, Paul L.
    Kusek, John W.
    Raj, Dominic S.
    [J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 11 (09): : 1546 - 1556
  • [3] Baylis D, 2013, LONGEV HLTH, V1, P1
  • [4] Bordoni Valeria, 2005, Curr Drug Discov Technol, V2, P29, DOI 10.2174/1570163053175457
  • [5] Biomarkers of inflammation in heart failure
    Bozkurt, Biykem
    Mann, Douglas L.
    Deswal, Anita
    [J]. HEART FAILURE REVIEWS, 2010, 15 (04) : 331 - 341
  • [6] Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
    Bruunsgaard, H
    Ladelund, S
    Pedersen, AN
    Schroll, M
    Jorgensen, T
    Pedersen, BK
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2003, 132 (01) : 24 - 31
  • [7] Elevated levels of tumor necrosis factor alpha and mortality in centenarians
    Bruunsgaard, H
    Andersen-Ranberg, K
    Hjelmborg, JVB
    Pedersen, BK
    Jeune, B
    [J]. AMERICAN JOURNAL OF MEDICINE, 2003, 115 (04) : 278 - 283
  • [8] Age-related inflammatory cytokines and disease
    Brüünsgaard, H
    Pedersen, BK
    [J]. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2003, 23 (01) : 15 - +
  • [9] Cicha I., 2015, Int J Interf Cytokine Mediat Res, V7, P9, DOI 10.2147/IJICMR.S64894
  • [10] Role of tumor necrosis factor-alpha in the pathogenesis of atrial fibrillation
    Deng Hai
    Xue Yu-mei
    Zhan Xian-zhang
    Liao Hong-tao
    Guo Hui-ming
    Wu Shu-lin
    [J]. CHINESE MEDICAL JOURNAL, 2011, 124 (13) : 1976 - 1982