Fosmidomycin, a specific inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis

被引：339
|
作者：
Kuzuyama, T [1 ]
Shimizu, T [1 ]
Takahashi, S [1 ]
Seto, H [1 ]
机构：
[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 43期
基金：
日本学术振兴会;
关键词：
inhibitor; fosmidomycin; 2-C-methylerythrose; 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase;
D O I：
10.1016/S0040-4039(98)01755-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Fosmidomycin inhibited 1-deoxy-D-xylulose 5-phosphate reductoisomerase in an alternative nonmevalonate pathway for terpenoid biosynthesis with IC50 of 8.2 nM. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7913 / 7916
页数：4
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