Fosmidomycin, a specific inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis

被引：340

作者：

Kuzuyama, T ^{[1
]}

Shimizu, T ^{[1
]}

Takahashi, S ^{[1
]}

Seto, H ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 43期

基金：

日本学术振兴会;

关键词：

inhibitor; fosmidomycin; 2-C-methylerythrose; 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase;

D O I：

10.1016/S0040-4039(98)01755-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fosmidomycin inhibited 1-deoxy-D-xylulose 5-phosphate reductoisomerase in an alternative nonmevalonate pathway for terpenoid biosynthesis with IC50 of 8.2 nM. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7913 / 7916

页数：4

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