Diagnostic and prognostic significance of serum angiopoietin-1 and-2 concentrations in patients with pulmonary hypertension

被引：9

作者：

Enomoto, Noriyuki ^{[1
,2
]}

Suzuki, Seiichiro ^{[1
]}

Hozumi, Hironao ^{[1
]}

Karayama, Masato ^{[1
]}

Suzuki, Yuzo ^{[1
]}

Furuhashi, Kazuki ^{[1
]}

Fujisawa, Tomoyuki ^{[1
]}

Nakamura, Yutaro ^{[1
]}

Odagiri, Keiichi ^{[3
,4
]}

Ishikawa, Takamichi ^{[5
]}

Kataoka, Kensuke ^{[6
]}

Kondoh, Yasuhiro ^{[6
]}

Maekawa, Masato ^{[7
]}

Inui, Naoki ^{[1
,3
]}

Watanabe, Hiroshi ^{[3
]}

Suda, Takafumi ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Internal Med, Div 2, Hamamatsu, Shizuoka, Japan

[2] Hamamatsu Univ Sch Med, Hlth Adm Ctr, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan

[3] Hamamatsu Univ Sch Med, Dept Clin Pharmacol & Therapeut, Hamamatsu, Shizuoka, Japan

[4] Hamamatsu Univ Hosp, Ctr Clin Res, Hamamatsu, Shizuoka, Japan

[5] Hamamatsu Univ Sch Med, Dept Pediat, Hamamatsu, Shizuoka, Japan

[6] Tosei Gen Hosp, Dept Resp Med & Allergy, Seto, Aichi, Japan

[7] Hamamatsu Univ Sch Med, Dept Lab Med, Hamamatsu, Shizuoka, Japan

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

EDEMA;

D O I：

10.1038/s41598-021-94907-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several biomarkers for detecting pulmonary hypertension (PH) have been reported. However, these biomarkers are deemed insufficient to detect PH in its early stages. We evaluated the utility of serum angiopoietin (ANGP), a glycoprotein related to angiogenesis, as a diagnostic and prognostic biomarker of PH. Patients with PH who underwent right-heart catheterization, were retrospectively studied. Serum concentrations of ANGP-1 and ANGP-2 were measured using an enzyme-linked immunosorbent assay in patients with PH (n=32), those with idiopathic pulmonary fibrosis (IPF) without PH (as a disease control, n=75), and age-matched healthy controls (HC, n=60). Nineteen patients (59.4%) with PH had World Health Organization group 3 PH. Serum ANGP-2 concentration, but not ANGP-1, in patients with PH was significantly higher compared with that in HC (p=0.025) and in patients with IPF without PH (p=0.008). Serum ANGP-2 concentration in patients with PH positively and significantly correlated with N-terminal pro-B-type natriuretic peptide (r=0.769, p<0.001), right ventricular diameter on echocardiography (r=0.565, p=0.035), and mean pulmonary arterial pressure (r=0.449, p=0.032) and pulmonary vascular resistance (r=0.451, p=0.031) on right-heart catheterization. ANGP-1 and ANGP-2 were expressed on lung vascular endothelial cells, as shown by immunohistochemistry. Patients with PH with higher ANGP-2 concentration (<greater than or equal to>2.48 ng/mL) had significantly worse survival (p=0.022). Higher ANGP-2 concentration was a significant worse prognostic factor (hazard ratio=6.063, p=0.037), while serum ANGP-1 concentration was not. In conclusion, serum ANGP-2 may be a useful diagnostic and prognostic biomarker in patients with PH, especially in patients with group 3 PH.

引用

页数：12

共 27 条

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