Biomarkers in renal cell carcinoma: Are we there yet?

被引：16

作者：

Gulati, Shuchi ^{[1
]}

Vogelzang, Nicholas J. ^{[2
]}

机构：

[1] Univ Cincinnati, Div Hematol & Oncol, Cincinnati, OH 45221 USA

[2] Nevada Canc Res Fdn, Las Vegas, NV USA

来源：

ASIAN JOURNAL OF UROLOGY | 2021年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Kidney cancer; Clear cell; Non-clear cell; Immunotherapy; Biomarkers; COMPREHENSIVE MOLECULAR CHARACTERIZATION; TO-LYMPHOCYTE RATIO; TARGETED THERAPY; GENE-MUTATIONS; TUMOR DNA; EXPRESSION; SUNITINIB; PAZOPANIB; NIVOLUMAB; SURVIVAL;

D O I：

10.1016/j.ajur.2021.05.013

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Management of kidney cancer has undergone a paradigm shift with the approval of new therapies over the last two decades. Although these drugs have improved clinical out-comes in patients with kidney cancer, there are still a large number of patients who do not show objective responses. A multitude of investigators, including those for The Cancer Genome Atlas have biologically characterized and sub-classified kidney cancer. However, we have not been able to identify molecular targets to effectively treat patients with kidney cancer. As we familiarize ourselves with newer drugs for patients with kidney cancer, it is important to understand that these drugs may not work in every patient and instead may expose patients to unnecessary toxic effects along with burdening society with the financial impact. As we head toward the era of "precision medicine", validated biomarkers are being utilized to guide treatment choices and help identify pathways of resistance in other tumor types. The current review aims at evaluating the progress made so far in this realm for patients with kidney cancer. (C) 2021 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V.

引用

页码：362 / 375

页数：14

共 103 条

[1]

[Anonymous], FDA APPROVES PEMBROL

[2]

[Anonymous], 2018, KIDNEY CANCER

[3] Pretreatment neutrophil-to-lymphocyte ratio as a marker of outcomes in nivolumab-treated patients with advanced non-small-cell lung cancer [J].

Bagley, Stephen J. ;

Kothari, Shawn ;

Aggarwal, Charu ;

Bauml, Joshua M. ;

Alley, Evan W. ;

Evans, Tracey L. ;

Kosteva, John A. ;

Ciunci, Christine A. ;

Gabriel, Peter E. ;

Thompson, Jeffrey C. ;

Stonehouse-Lee, Susan ;

Sherry, Victoria E. ;

Gilbert, Elizabeth ;

Eaby-Sandy, Beth ;

Mutale, Faith ;

DiLullo, Gloria ;

Cohen, Roger B. ;

Vachani, Anil ;

Langer, Corey J. .

LUNG CANCER, 2017, 106 :1-7

[4] Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma [J].

Bakouny, Ziad ;

Braun, David A. ;

Shukla, Sachet A. ;

Pan, Wenting ;

Gao, Xin ;

Hou, Yue ;

Flaifel, Abdallah ;

Tang, Stephen ;

Bosma-Moody, Alice ;

He, Meng Xiao ;

Vokes, Natalie ;

Nyman, Jackson ;

Xie, Wanling ;

Nassar, Amin H. ;

Abou Alaiwi, Sarah ;

Flippot, Ronan ;

Bouchard, Gabrielle ;

Steinharter, John A. ;

Nuzzo, Pier Vitale ;

Ficial, Miriam ;

Sant'Angelo, Miriam ;

Forman, Juliet ;

Berchuck, Jacob E. ;

Dudani, Shaan ;

Bi, Kevin ;

Park, Jihye ;

Camp, Sabrina ;

Sticco-Ivins, Maura ;

Hirsch, Laure ;

Baca, Sylvan C. ;

Wind-Rotolo, Megan ;

Ross-Macdonald, Petra ;

Sun, Maxine ;

Lee, Gwo-Shu Mary ;

Chang, Steven L. ;

Wei, Xiao X. ;

McGregor, Bradley A. ;

Harshman, Lauren C. ;

Genovese, Giannicola ;

Ellis, Leigh ;

Pomerantz, Mark ;

Hirsch, Michelle S. ;

Freedman, Matthew L. ;

Atkins, Michael B. ;

Wu, Catherine J. ;

Ho, Thai H. ;

Linehan, W. Marston ;

McDermott, David F. ;

Heng, Daniel Y. C. ;

Viswanathan, Srinivas R. .

NATURE COMMUNICATIONS, 2021, 12 (01)

[5] Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma [J].

Braun, David A. ;

Hou, Yue ;

Bakouny, Ziad ;

Ficial, Miriam ;

Sant' Angelo, Miriam ;

Forman, Juliet ;

Ross-Macdonald, Petra ;

Berger, Ashton C. ;

Jegede, Opeyemi A. ;

Elagina, Liudmilla ;

Steinharter, John ;

Sun, Maxine ;

Wind-Rotolo, Megan ;

Pignon, Jean-Christophe ;

Cherniack, Andrew D. ;

Lichtenstein, Lee ;

Neuberg, Donna ;

Catalano, Paul ;

Freeman, Gordon J. ;

Sharpe, Arlene H. ;

McDermott, David F. ;

Van Allen, Eliezer M. ;

Signoretti, Sabina ;

Wu, Catherine J. ;

Shukla, Sachet A. ;

Choueiri, Toni K. .

NATURE MEDICINE, 2020, 26 (06) :909-+

[6] ClearCode34: A Prognostic Risk Predictor for Localized Clear Cell Renal Cell Carcinoma [J].

Brooks, Samira A. ;

Brannon, A. Rose ;

Parker, Joel S. ;

Fisher, Jennifer C. ;

Sen, Oishee ;

Kattan, Michael W. ;

Hakimi, A. Ari ;

Hsieh, James J. ;

Choueiri, Toni K. ;

Tamboli, Pheroze ;

Maranchie, Jodi K. ;

Hinds, Peter ;

Miller, C. Ryan ;

Nielsen, Matthew E. ;

Rathmell, W. Kimryn .

EUROPEAN UROLOGY, 2014, 66 (01) :77-84

[7]

Buscheck Franziska, 2020, Oncotarget, V11, P237, DOI 10.18632/oncotarget.27428

[8] Differential Expression of PD-L1 between Primary and Metastatic Sites in Clear-Cell Renal Cell Carcinoma [J].

Callea, Marcella ;

Albiges, Laurence ;

Gupta, Mamta ;

Cheng, Su-Chun ;

Genega, Elizabeth M. ;

Fay, Andre P. ;

Song, Jiaxi ;

Carvo, Ingrid ;

Bhatt, Rupal S. ;

Atkins, Michael B. ;

Hodi, F. Stephen ;

Choueiri, Toni K. ;

McDermott, David F. ;

Freeman, Gordon J. ;

Signoretti, Sabina .

CANCER IMMUNOLOGY RESEARCH, 2015, 3 (10) :1158-1164

[9] Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer [J].

Carbone, Michele ;

Harbour, J. William ;

Brugarolas, James ;

Bononi, Angela ;

Pagano, Ian ;

Dey, Anwesha ;

Krausz, Thomas ;

Pass, Harvey, I ;

Yang, Haining ;

Gaudino, Giovanni .

CANCER DISCOVERY, 2020, 10 (08) :1103-1120

[10] Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology [J].

Cheng, Donavan T. ;

Mitchell, Talia N. ;

Zehir, Ahmet ;

Shah, Ronak H. ;

Benayed, Ryma ;

Syed, Aijazuddin ;

Chandramohan, Raghu ;

Liu, Zhen Yu ;

Won, Helen H. ;

Scott, Sasinya N. ;

Brannon, A. Rose ;

O'Reilly, Catherine ;

Sadowska, Justyna ;

Casanova, Jacklyn ;

Yannes, Angela ;

Hechtman, Jaclyn F. ;

Yao, Jinjuan ;

Song, Wei ;

Ross, Dara S. ;

Oultache, Alifya ;

Dogan, Snjezana ;

Borsu, Laetitia ;

Hameed, Meera ;

Nafa, Khedoudja ;

Arcila, Maria E. ;

Ladanyi, Marc ;

Berger, Michael F. .

JOURNAL OF MOLECULAR DIAGNOSTICS, 2015, 17 (03) :251-264

← 1 2 3 4 5 6 7 8 9 10 →