How to improve the immunogenicity of chemotherapy and radiotherapy

被引：66

作者：

Ma, Yuting ^{[1
,2
]}

Conforti, Rosa ^{[1
,2
]}

Aymeric, Laetitia ^{[1
,2
]}

Locher, Clara ^{[1
,2
]}

Kepp, Oliver ^{[3
]}

Kroemer, Guido ^{[3
,4
,5
,7
]}

Zitvogel, Laurence ^{[1
,2
,6
]}

机构：

[1] Inst Gustave Roussy, INSERM, U1015, F-94805 Villejuif, France

[2] Univ Paris 11, F-94805 Villejuif, France

[3] INSERM, U848, Villejuif, France

[4] Hop Europeen Georges Pompidou, AP HP, Paris, France

[5] Univ Paris 05, Paris, France

[6] Inst Gustave Roussy, CICBT507, Villejuif, France

[7] Ctr Rech Cordeliers, Paris, France

来源：

CANCER AND METASTASIS REVIEWS | 2011年 / 30卷 / 01期

关键词：

Cell death; DAMP; Tumor microenvironment; Immune cells; REGULATORY T-CELLS; COLONY-STIMULATING FACTOR; CD8(+) DENDRITIC CELLS; AUGMENTS ANTITUMOR IMMUNITY; RECEPTOR TYROSINE KINASES; INHIBITS TUMOR-GROWTH; HEAT-SHOCK PROTEINS; APOPTOTIC CELLS; CALRETICULIN EXPOSURE; NK CELLS;

D O I：

10.1007/s10555-011-9283-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapy or radiotherapy could induce various tumor cell death modalities, releasing tumor-derived antigen as well as danger signals that could either be captured for triggering antitumor immune response or ignored. Exploring the interplay among therapeutic drugs, tumor cell death and the immune cells should improve diagnostic, prognostic, predictive, and therapeutic management of tumor. We summarized some of the cell death-derived danger signals and the mechanism for host to sense and response to cell death in the tumor microenvironment. Based on the recent clinical or experimental findings, several strategies have been suggested to improve the immunogenicity of cell death and augment antitumor immunity.

引用

页码：71 / 82

页数：12

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