Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma

被引：24

作者：

Karami, S. ^{[1
]}

Brennan, P. ^{[2
]}

Navratilova, M. ^{[3
]}

Mates, D. ^{[4
]}

Zaridze, D. ^{[5
]}

Janout, V. ^{[6
]}

Kollarova, H. ^{[6
]}

Bencko, V. ^{[7
]}

Matveev, V. ^{[5
]}

Szesznia-Dabrowska, N. ^{[8
]}

Holcatova, I. ^{[7
]}

Yeager, M. ^{[9
]}

Chanock, S. ^{[9
]}

Rothman, N. ^{[1
]}

Boffetta, P. ^{[2
]}

Chow, W-H. ^{[1
]}

Moore, L. E. ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA

[2] Int Agcy Res Canc, F-69372 Lyon, France

[3] Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic

[4] Inst Publ Hlth, Bucharest, Romania

[5] Russian Acad Med Sci, Canc Res Ctr, Inst Carcinogenesis, Moscow, Russia

[6] Palacky Univ, Fac Med, Dept Prevent Med, CR-77147 Olomouc, Czech Republic

[7] Charles Univ Prague, Fac Med 1, Inst Hyg & Epidemiol, CR-11636 Prague 1, Czech Republic

[8] Inst Occupat Med, Dept Epidemiol, Lodz, Poland

[9] Bethseda Natl Canc Inst, Core Genotyping Facil, Adv Technol Ctr, NIH,Dept Hlth & Human Serv, Bethesda, MD USA

来源：

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2010年 / 2010卷

关键词：

D-RECEPTOR GENE; ULTRAVIOLET-RADIATION; FISH CONSUMPTION; KIDNEY CANCER; SUN EXPOSURE; POLYMORPHISMS; SUSCEPTIBILITY; EPIDEMIOLOGY; HAPLOTYPE; GENOTYPES;

D O I：

10.1155/2010/879362

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Variation in both genes has been shown to modify renal cell carcinoma (RCC) risk. Therefore, we investigated whether VDR and RXRA polymorphisms modify associations between RCC risk and frequency of dietary intake of vitamin D and calcium rich foods, and occupational ultraviolet exposure among 777 RCC case and 1035 controls from Central and Eastern Europe. A positive association was observed in this population between increasing dietary intake frequency of yogurt, while an inverse association was observed with egg intake frequency. RXRA polymorphisms, located 3' of the coding sequence, modified associations between specific vitamin D rich foods and RCC risk, while RXRA polymorphisms, located in introns 1 and 4, modified associations with specific calcium rich foods. Results suggest that variants in the RXRA gene modified the associations observed between RCC risk and calcium and vitamin D intake.

引用

页数：11

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