Assessment of Fibrosis and Cirrhosis in Liver Biopsies: An Update

被引:88
作者
Germani, Giacomo [2 ,3 ,4 ]
Hytiroglou, Prodromos [5 ]
Fotiadu, Anastasia [5 ]
Burroughs, Andrew K. [2 ,3 ,4 ]
Dhillon, Amar P. [1 ]
机构
[1] UCL Med Sch, Dept Cellular Pathol, London NW3 2PF, England
[2] Royal Free Sheila Sherlock Liver Ctr, London, England
[3] Univ Dept Surg UCL, London, England
[4] Royal Free Hosp, London NW3 2QG, England
[5] Aristotle Univ Thessaloniki, Sch Med, Dept Pathol, GR-54006 Thessaloniki, Greece
关键词
Biopsy; cirrhosis; collagen; fibrosis; hepatitis; liver; stage; CHRONIC HEPATITIS-C; VENOUS-PRESSURE GRADIENT; CHRONIC VIRAL-HEPATITIS; HISTOLOGICAL-HEMODYNAMIC CORRELATION; PREDICTS CLINICAL DECOMPENSATION; COLLAGEN PROPORTIONATE AREA; CHRONIC ACTIVE HEPATITIS; ASSISTED IMAGE-ANALYSIS; HISTOPATHOLOGICAL ASSESSMENT; QUANTITATIVE ASSESSMENT;
D O I
10.1055/s-0031-1272836
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The liver biopsy specimen represents valuable material for the assessment of fibrosis and cirrhosis. Despite limitations related to sampling and interpretation, histologic examination remains the gold standard for staging chronic liver diseases. Hepatic fibrosis is currently viewed as a dynamic process that may often regress after successful treatment of chronic liver diseases. Even the excess fibrous tissue of cirrhotic livers may sometimes regress over time. Distinguishing between the amount of hepatic fibrosis and the disease stage is important for the assessment of the effects of antifibrotic treatments. Recent studies suggest that the proportion of the liver biopsy specimen occupied by collagen is correlated with the hepatic venous pressure gradient in liver transplant recipients with hepatitis C virus infection, with or without cirrhosis, and represents a predictor of clinical decompensation. This parameter has also been found to correlate with liver stiffness measurements of patients with chronic viral hepatitis obtained by transient elastography. Therefore, quantitative assessment of hepatic fibrosis in liver biopsy specimens holds promise as a prognostic marker, and as a means to validate noninvasive markers of fibrosis.
引用
收藏
页码:82 / 90
页数:9
相关论文
共 80 条
  • [71] LIVER-BIOPSY IN CHRONIC AGGRESSIVE HEPATITIS - DIAGNOSTIC REPRODUCIBILITY IN RELATION TO SIZE OF SPECIMEN
    SCHLICHTING, P
    HOLUND, B
    POULSEN, H
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1983, 18 (01) : 27 - 32
  • [72] Direct and indirect evidence for the reversibility of cirrhosis
    Serpaggi, Jeanne
    Carnot, Francoise
    Nalpas, Bertrand
    Canioni, Daniele
    Guechot, Jerome
    Lebray, Pascal
    Vallet-Pichard, Anais
    Fontaine, Helene
    Bedossa, Pierre
    Pot, Stanislas
    [J]. HUMAN PATHOLOGY, 2006, 37 (12) : 1519 - 1526
  • [73] An appraisal of the histopathological assessment of liver fibrosis
    Standish, RA
    Cholongitas, E
    Dhillon, A
    Burroughs, AK
    Dhillon, AP
    [J]. GUT, 2006, 55 (04) : 569 - 578
  • [74] The therapeutic and prognostic benefit of portal pressure reduction in cirrhosis
    Triantos, C. K.
    Nikolopoulou, V.
    Burroughs, A. K.
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2008, 28 (08) : 943 - 952
  • [75] WEDGED HEPATIC VENOUS-PRESSURE RECORDING AND VENOGRAPHY FOR THE ASSESSMENT OF PRE-CIRRHOTIC AND CIRRHOTIC LIVER-DISEASE
    VANLEEUWEN, DJ
    SHERLOCK, S
    SCHEUER, PJ
    DICK, R
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1989, 24 (01) : 65 - 73
  • [76] VARGASTANK L, 1985, LIVER, V5, P178
  • [77] QUANTITATIVE HISTOLOGICAL ASSESSMENT IN CIRRHOSIS: SEPTAL THICKNESS PREDICTS CLINICAL DECOMPENSATION
    Viola, A.
    Jain, D.
    Garcia-Tsao, G.
    [J]. JOURNAL OF HEPATOLOGY, 2009, 50 : S94 - S94
  • [78] Wanless IR, 2000, ARCH PATHOL LAB MED, V124, P1599
  • [79] Wanless IR, 2007, MACSWEENS PATHOLOGY, P613
  • [80] Relationships between fibrosis amounts assessed by morphometry and liver stiffness measurements in chronic hepatitis or steatohepatitis
    Ziol, Marianne
    Kettaneh, Adrien
    Ganne-Carrie, Nathalie
    Barget, Nathalie
    Tengher-Barna, Iulia
    Beaugrand, Michel
    [J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2009, 21 (11) : 1261 - 1268