Molecular and Circulating Biomarkers in Patients with Glioblastoma

被引:31
|
作者
Senhaji, Nadia [1 ,2 ]
Squalli Houssaini, Asmae [2 ]
Lamrabet, Salma [2 ]
Louati, Sara [3 ]
Bennis, Sanae [2 ]
机构
[1] Moulay Ismail Univ, Fac Sci, Dept Biol, Meknes 50000, Morocco
[2] Sidi Mohamed Ben Abdellah Univ, Fac Med Pharm & Dent Med Fez, Lab Biomed & Translat Res, Fes 30070, Morocco
[3] Mohammed Vth Univ, Fac Med & Pharm Rabat, Med Biotechnol Lab, Rabat 10000, Morocco
基金
英国科研创新办公室;
关键词
glioblastoma; molecular biomarkers; liquid biopsy; ENDOTHELIAL GROWTH-FACTOR; CENTRAL-NERVOUS-SYSTEM; DNA-REPAIR GENE; O-6-METHYLGUANINE-DNA METHYLTRANSFERASE MGMT; NEWLY-DIAGNOSED GLIOBLASTOMA; KI-67/MIB-1 LABELING INDEX; LONG NONCODING RNA; BRAIN-TUMOR CELLS; PROMOTER METHYLATION; BREAST-CANCER;
D O I
10.3390/ijms23137474
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glioblastoma is the most aggressive malignant tumor of the central nervous system with a low survival rate. The difficulty of obtaining this tumor material represents a major limitation, making the real-time monitoring of tumor progression difficult, especially in the events of recurrence or resistance to treatment. The identification of characteristic biomarkers is indispensable for an accurate diagnosis, the rigorous follow-up of patients, and the development of new personalized treatments. Liquid biopsy, as a minimally invasive procedure, holds promise in this regard. The purpose of this paper is to summarize the current literature regarding the identification of molecular and circulating glioblastoma biomarkers and the importance of their integration as a valuable tool to improve patient care.
引用
收藏
页数:30
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