The effects of herbal medicines on cancer therapy-induced oral mucositis: A literature review

被引：9
作者：
Safarzadeh, Saba [1 ]
Shirban, Farinaz [2 ]
Bagherniya, Mohammad [3 ,4 ,5 ]
Sathyapalan, Thozhukat [6 ]
Sahebkar, Amirhossein [7 ,8 ,9 ,10 ]
机构：
[1] Isfahan Univ Med Sci, Sch Dent, Dept Orthodont, Dent Students Res Comm, Esfahan, Iran
[2] Isfahan Univ Med Sci, Dent Res Inst, Sch Dent, Dept Orthodont,Dent Res Ctr, Esfahan, Iran
[3] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran
[4] Isfahan Univ Med Sci, Anesthesia & Crit Care Res Ctr, Esfahan, Iran
[5] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran
[6] Univ Hull, Hull York Med Sch, Dept Acad Diabet Endocrinol & Metab, Kingston Upon Hull, N Humberside, England
[7] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran
[8] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran
[9] Univ Western Australia, Sch Med, Perth, WA, Australia
[10] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran
来源：
PHYTOTHERAPY RESEARCH | 2022年 / 36卷 / 01期
关键词：
cancer; chemotherapy; herbal medicine; oral mucositis; radiotherapy; HANGE-SHASHIN-TO; KOREAN RED GINSENG; ALOE-VERA; NECK-CANCER; PHASE-III; KAMPO MEDICINE; PROSTAGLANDIN-E2; PRODUCTION; CISPLATIN NEPHROTOXICITY; ANTIOXIDANT ACTIVITY; PROPOLIS EXTRACT;
D O I：
10.1002/ptr.7308
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cancer therapy-induced oral mucositis (OM) is one of the most troublesome morbidities after radio-chemotherapy. Age, nutritional status, tumor type, oral hygiene, and treatment method are the determinants for OM incidence. In addition, oxygen-free radicals can act as a trigger for an inflammatory milieu that causes OM. Based on the debilitating nature of OM, finding a safe and inexpensive agent with anti-inflammatory, anti-microbial, and antioxidative properties can be valuable for this situation. Considering the harmful effects of some chemical agents, herbal medicine has been suggested as a potential alternative owing to unique properties such as safety, availability and low cost. Many studies have illustrated several pharmacological properties of herbal medicines in recent years, such as anti-inflammatory, anti-microbial, and antioxidative activities, which are essential factors in the palliation of cancer therapy-induced OM. This review aimed to evaluate herbal medicines' effects on cancer therapy-induced OM. According to this comprehensive review, it is concluded that medicinal plants and phytochemicals can be used as practical agents in the palliation of cancer therapy-induced OM without any serious side effects.
引用
收藏
页码：243 / 265
页数：23
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