Relationship between nuclear morphometry, DNA content and resectability of pancreatic cancer

被引:6
作者
He, YC [1 ]
Peng, W
Qiao, JG
Cao, J
Chen, LW
机构
[1] Wuhan Univ, Zhongnan Hosp, Dept Gen Surg, Wuhan 430071, Peoples R China
[2] Jingmen Tech Coll, Coll Med, Jingmen 448000, Hubei, Peoples R China
关键词
D O I
10.3748/wjg.v9.i8.1863
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To investigate the association of nuclear morphometry and DNA content with resectability of pancreatic cancer. METHODS: A total of 36 patients with pancreatic adenocarcinoma were divided into resectable group and unresectable group. The nuclear morphometry and DNA contents of tumor cells were analyzed by IBAS autoimagine analyzer from paraffin-embedded materials. Localization size, histological type and grade, and clinical stage of the tumor were evaluated. Factors influencing resectability of pancreatic cancer were investigated using stepwise regression analysis. RESULTS: Statistical significance was found in nuclear DNA content (integrated optical density, IOD) of tumor cells (1.64+/-0.41 vs 2.96+/-0.55), DNA ploidy, ages (46.5+/-5.3 years vs 58.6+/-0.7 years) and tumor volumes (298.1+/-101.5 cm(3) vs 634.7+/-512.5 cm(3)) in both groups (P<0.05), and no difference was found in the nuclear morphometry (P>0.05). The rates of diploid/tetraploid and aneuploid were 66.7 % and 33.3 % in resectable group respectively, and 38.9 % and 62.1 % in unresectable group, respectvely (P<0.05). IOD (X-12), ploidy status (X-13) and clinical stage (X-3) were radical resectable indicators with statistical significance. The regression equation for resectability was Y=-9,2053+3.5428X(12)+2.5390X(13)-2.3001X(3) (RR=0.8780, P<0.01). CONCLUSION: There is a high correlation between resectability of pancreatic cancers and their DNA contents, DNA ploidy status and clinical stage.
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收藏
页码:1863 / 1865
页数:3
相关论文
共 30 条
[11]   Laparoscopy with laparoscopic ultrasonography in the TNM staging of pancreatic carcinoma [J].
John, TG ;
Wright, A ;
Allan, PL ;
Redhead, DN ;
Paterson-Brown, S ;
Carter, DC ;
Garden, OJ .
WORLD JOURNAL OF SURGERY, 1999, 23 (09) :870-881
[12]   Relationship between expression of E-cadherin-catenin complex and clinicopathologic characteristics of pancreatic cancer [J].
Li, YJ ;
Ji, XR .
WORLD JOURNAL OF GASTROENTEROLOGY, 2003, 9 (02) :368-372
[13]   Prognostic factors following curative resection for pancreatic adenocarcinoma - A population-based, linked database analysis of 396 patients [J].
Lim, JE ;
Chien, MW ;
Earle, CC .
ANNALS OF SURGERY, 2003, 237 (01) :74-85
[14]  
Liu B, 2001, WORLD J GASTROENTERO, V7, P143
[15]   Positive peritoneal cytology predicts unresectability of pancreatic adenocarcinoma [J].
Merchant, NB ;
Conlon, KC ;
Saigo, P ;
Dougherty, E ;
Brennan, MF .
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 1999, 188 (04) :421-426
[16]   DNA ploidy and Markovian analysis of neoplastic progression in experimental pancreatic cancer [J].
Postier, RG ;
Lerner, MR ;
Lightfoot, SA ;
Vannarath, R ;
Lane, MM ;
Hanas, JS ;
Brackett, DJ .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2003, 51 (03) :303-309
[17]  
Saftoiu Adrian, 2002, Rom J Gastroenterol, V11, P78
[18]   TNM staging and assessment of resectability of pancreatic cancer by laparoscopic ultrasonography [J].
Scheel-Hincke, JD ;
Mortensen, MB ;
Qvist, N ;
Hovendal, CP .
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 1999, 13 (10) :967-971
[19]  
Shankar A, 2001, WORLD J GASTROENTERO, V7, P622
[20]   Resected adenocarcinoma of the pancreas - 616 patients: Results, outcomes, and prognostic indicators [J].
Sohn, TA ;
Yeo, CJ ;
Cameron, JL ;
Koniaris, L ;
Kaushal, S ;
Abrams, RA ;
Sauter, PK ;
Coleman, J ;
Hruban, RH ;
Lillemoe, KD .
JOURNAL OF GASTROINTESTINAL SURGERY, 2000, 4 (06) :567-579