Borrelia-like organism in heart capillaries of patient with Lyme-disease seen by electron microscopy

被引：7

作者：

Lalosevic, Dusan ^{[1
,2
]}

Lalosevic, Vesna ^{[3
]}

Stojsic-Milosavljevic, Anastazija ^{[4
]}

Stojsic, Djurica ^{[4
]}

机构：

[1] Fac Med, Dept Histol & Embryol, Novi Sad 21000, Serbia

[2] Clin Ctr Vojvodina, Novi Sad, Serbia

[3] Fac Agr, Dept Vet Med, Novi Sad, Serbia

[4] Inst Cardiovasc Dis, Sremska Kamenica, Serbia

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2010年 / 145卷 / 03期

关键词：

Lyme borreliosis; Clinical case; Endomyocardial biopsy; Ultrastructure; ULTRASTRUCTURAL DEMONSTRATION; BURGDORFERI;

D O I：

10.1016/j.ijcard.2008.12.165

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A case of a patient who developed an acute myocarditis due to Lyme disease is reported. An increased serum antibody titer to Borrelia burgdorferi suggested a diagnosis and in addition of basic clinical methods, endomyocardial biopsy performed and analyzed by transmission electron microscopy. The lumen of myocardial capillaries was founded mostly filled with detritus and fibrin precipitate, between them several bacterial fragments were identified. The electron-microscopic characteristics of the microorganisms in this specimen, revealing irregularly coiled appearance and consistent thickness of 0.2 mu m, correspond to the spiral-like structure of Lyme disease borrelia. The presence of fibrin deposits on the capillary endothelium and necrosis of myocardiocytes, suggests that the cardiopathy in our patient was represent borrelia-mediated damage of the hearth microcirculation. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E96 / E98

页数：3

共 16 条

[1]

Bartunek P, 2006, Prague Med Rep, V107, P213

[2]

Bartunek P, 2001, WIEN KLIN WOCHENSCHR, V113, P38

[3] Transformation of cystic forms of Borrelia burgdorferi to normal, mobile spirochetes [J].

Brorson, O ;

Brorson, SH .

INFECTION, 1997, 25 (04) :240-246

[4] Cardiac involvement in non-human primates infected with the Lyme disease spirochete Borrelia burgdorferi [J].

Cadavid, D ;

Bai, YH ;

Hodzic, E ;

Narayan, K ;

Barthold, SW ;

Pachner, AR .

LABORATORY INVESTIGATION, 2004, 84 (11) :1439-1450

[5]

Chary-Valckenaere I, 1998, BRIT J RHEUMATOL, V37, P468

[6] Ethical authorship and publishing [J].

Coats, Andrew J. S. .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2009, 131 (02) :149-150

[7] DEMONSTRATION OF SPIROCHETES IN CARDIAC BIOPSIES OF PATIENTS WITH LYME-DISEASE [J].

DEKONING, J ;

HOOGKAMPKORSTANJE, JAA ;

VANDERLINDE, MR ;

CRIJNS, HJGM .

JOURNAL OF INFECTIOUS DISEASES, 1989, 160 (01) :150-153

[8]

DEKONING J, 1995, J CUTAN PATHOL, V22, P23

[9]

DEKONING P, 1986, ZENTRALBL BAKTERIO A, V263, P179

[10]

HARRIS NL, 2002, NEW ENGL J MED, V346, P1732

← 1 2 →