DNA vaccination for HIV-1 and SIV

被引：26
作者：
Barouch, DH
Letvin, NL
机构：
[1] Harvard Univ, Sch Med, Boston, MA 02215 USA
[2] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
来源：
INTERVIROLOGY | 2000年 / 43卷 / 4-6期
关键词：
DNA vaccine; immunization; genetic; HIV-1; SIV;
D O I：
10.1159/000053995
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Control of the worldwide AIDS epidemic will only be achieved with a safe and effective prophylactic HIV-1 vaccine. DNA vaccination has recently emerged as a promising vaccine modality that can elicit both humoral and cellular immune responses. HIV-1- and SIV-specific immune responses have been elicited by DNA vaccines in both mice and nonhuman primates. However, these immune responses have not been capable of protecting nonhuman primates against pathogenic AIDS virus challenges. A number of approaches are therefore being investigated to augment DNA vaccine-elicited immune responses. Copyright (C) 2001 S. Karger AG, Basel.
引用
收藏
页码：282 / 287
页数：6
相关论文
共 60 条
[1]  
Barouch DH, 1998, J IMMUNOL, V161, P1875
[2]   VIRUS-SPECIFIC CD8+ CYTOTOXIC T-LYMPHOCYTE ACTIVITY ASSOCIATED WITH CONTROL OF VIREMIA IN PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION [J].
BORROW, P ;
LEWICKI, H ;
HAHN, BH ;
SHAW, GM ;
OLDSTONE, MBA .
JOURNAL OF VIROLOGY, 1994, 68 (09) :6103-6110
[3]   Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination [J].
Boyer, JD ;
Ugen, KE ;
Wang, B ;
Agadjanyan, M ;
Gilbert, L ;
Bagarazzi, ML ;
Chattergoon, M ;
Frost, P ;
Javadian, A ;
Williams, WV ;
Refaeli, Y ;
Ciccarelli, RB ;
McCallus, D ;
Coney, L ;
Weiner, DB .
NATURE MEDICINE, 1997, 3 (05) :526-532
[4]   Enhancement of cellular immune response in HIV-1 seropositive individuals: A DNA-based trial [J].
Boyer, JD ;
Chattergoon, MA ;
Ugen, KE ;
Shah, A ;
Bennett, M ;
Cohen, A ;
Nyland, S ;
Lacy, KE ;
Bagarazzi, ML ;
Higgins, TJ ;
Baine, Y ;
Ciccarelli, RB ;
Ginsberg, RS ;
MacGregor, RR ;
Weiner, DB .
CLINICAL IMMUNOLOGY, 1999, 90 (01) :100-107
[5]   Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients [J].
Calarota, S ;
Bratt, G ;
Nordlund, S ;
Hinkula, J ;
Leandersson, AC ;
Sandström, E ;
Wahren, B .
LANCET, 1998, 351 (9112) :1320-1325
[6]   Genetic immunization: a new era in vaccines and immune therapeutics [J].
Chattergoon, M ;
Boyer, J ;
Weiner, DB .
FASEB JOURNAL, 1997, 11 (10) :753-763
[7]   T-CELL RECEPTOR V-BETA REPERTOIRE IN AN ACUTE INFECTION OF RHESUS-MONKEYS WITH SIMIAN IMMUNODEFICIENCY VIRUSES AND A CHIMERIC SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS [J].
CHEN, ZW ;
KOU, ZC ;
LEKUTIS, C ;
SHEN, L ;
ZHOU, DJ ;
HALLORAN, M ;
LI, J ;
SODROSKI, J ;
LEEPARRITZ, D ;
LETVIN, NL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (01) :21-31
[8]   HIV/AIDS in 1998 - Gaining the upper hand? [J].
Cohen, OJ ;
Fauci, AS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (01) :87-88
[9]   DNA vaccines [J].
Donnelly, JJ ;
Ulmer, JB ;
Shiver, JW ;
Liu, MA .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :617-648
[10]   Gene gun-based nucleic acid immunization alone or in combination with recombinant vaccinia vectors suppresses virus burden in rhesus macaques challenged with a heterologous SIV [J].
Fuller, DH ;
Simpson, L ;
Cole, KS ;
Clements, JE ;
Panicali, DL ;
Montelaro, RC ;
MurpheyCorb, M ;
Haynes, JR .
IMMUNOLOGY AND CELL BIOLOGY, 1997, 75 (04) :389-396
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