LIPIDOMICS ERA: ACCOMPLISHMENTS AND CHALLENGES

被引：146

作者：

Khalil, Maroun Bou ^{[1
]}

Hou, Weimin ^{[1
]}

Zhou, Hu ^{[1
]}

Elisma, Fred ^{[1
]}

Swayne, Leigh Anne ^{[1
]}

Blanchard, Alexandre P. ^{[1
]}

Yao, Zemin ^{[1
]}

Bennett, Steffany A. L. ^{[1
]}

Figeys, Daniel ^{[1
]}

机构：

[1] Univ Ottawa, Dept Biochem Microbiol & Immunol, Fac Med, Ottawa, ON K1H 8M5, Canada

来源：

MASS SPECTROMETRY REVIEWS | 2010年 / 29卷 / 06期

关键词：

lipidomics; tandem mass spectrometry; systems biology; bioinformatics; identification; quantification; TANDEM MASS-SPECTROMETRY; ATMOSPHERIC-PRESSURE PHOTOIONIZATION; UNSATURATED FATTY-ACIDS; DOUBLE-BOND POSITION; THIN-LAYER-CHROMATOGRAPHY; FAST-ATOM-BOMBARDMENT; MALDI-TOF MS; COLLISIONAL-ACTIVATED DISSOCIATION; STAGE QUADRUPOLE INSTRUMENT; ION ELECTROSPRAY-IONIZATION;

D O I：

10.1002/mas.20294

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Lipid mediators participate in signal transduction pathways, proliferation, apoptosis, and membrane trafficking in the cell. Lipids are highly complex and diverse owing to the various combinations of polar headgroups, fatty acyl chains, and backbone structures. This structural diversity continues to pose a challenge for lipid analysis. Here we review the current state of the art in lipidomics research and discuss the challenges facing this field. The latest technological developments in mass spectrometry, the role of bioinformatics, and the applications of lipidomics in lipid metabolism and cellular physiology and pathology are also discussed. (C) 2010 Wiley Periodicals, Inc., Mass Spec Rev 29:877-929, 2010

引用

页码：877 / 929

页数：53

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