Increased risk of psychiatric disorders in adult patients with vitiligo: A nationwide, population-based cohort study in Taiwan

被引：27

作者：

Chen, Chih-Yu ^{[1
]}

Wang, Wei-Ming ^{[1
,2
]}

Chung, Chi-Hsiang ^{[3
,4
]}

Tsao, Chang-Huei ^{[5
,6
]}

Chien, Wu-Chien ^{[3
,5
,7
]}

Hung, Chih-Tsung ^{[1
,2
]}

机构：

[1] Triserv Gen Hosp, Dept Dermatol, Taipei, Taiwan

[2] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan

[3] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan

[4] Taiwanese Injury Prevent & Safety Promot Assoc, Taipei, Taiwan

[5] Triserv Gen Hosp, Dept Med Res, Taipei, Taiwan

[6] Natl Def Med Ctr, Dept Microbiol & Immunol, Taipei, Taiwan

[7] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan

来源：

JOURNAL OF DERMATOLOGY | 2020年 / 47卷 / 05期

关键词：

anxiety; major depressive disorder; manic disorder; psychiatric disorders; vitiligo; QUALITY-OF-LIFE; MAJOR DEPRESSION; ASSOCIATIONS;

D O I：

10.1111/1346-8138.15290

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Vitiligo is an autoimmune skin disease that has a major impact on the quality of life of patients. However, a nationwide study of the association between vitiligo and the incidence of inclusive psychiatric diseases has not been conducted in the Asian population. Therefore, this study aimed to analyze the association between vitiligo and the risk of psychiatric disorders using a nationwide database in Taiwan. Data were collected from the National Health Insurance Research Database of Taiwan from 2000 to 2013. In total, 1432 subjects with vitiligo and 5728 age-, sex- and index year-matched controls were enrolled in this study. Patients with vitiligo tend to have more coexisting psychiatric disorders than healthy individuals, regardless of their sex, age group and facility level of care. After adjusting for sex, age, comorbidity, urbanization and facility level of care, the adjusted hazard ratio of overall psychiatric disorders for patients with vitiligo was 2.926 (95% confidence interval [CI], 2.646-3.236; P < 0.001). Among them, the highest adjusted hazard ratios were found for obsessive-compulsive disorder, at 10.790 (95% CI, 9.756-11.932; P < 0.001). Vitiligo is associated with an increased risk of various psychiatric disorders. By providing a better understanding of the psychosocial burden associated with vitiligo, these results emphasize the need to evaluate the mental health of patients with vitiligo by treating physicians.

引用

页码：470 / 475

页数：6

共 29 条

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