Global DNA hypomethylation-induced ΔNp73 transcriptional activation in non-small cell lung cancer

被引：43

作者：

Daskalos, Alexandros ^{[1
]}

Logotheti, Stella ^{[2
]}

Markopoulou, Soultana ^{[1
]}

Xinarianos, George ^{[1
]}

Gosney, John R. ^{[3
]}

Kastania, Anastasia N. ^{[4
]}

Zoumpourlis, Vassilis ^{[2
]}

Field, John K. ^{[1
]}

Liloglou, Triantafillos ^{[1
]}

机构：

[1] Univ Liverpool, Roy Castle Lung Canc Res Programme, Dept Clin & Mol Canc Med, Liverpool L3 9TA, Merseyside, England

[2] Natl Hellen Res Fdn, Athens 11635, Greece

[3] Univ Liverpool, Sch Canc Studies, Div Pathol, Liverpool L3 9TA, Merseyside, England

[4] Acad Athens, Bioinformat & Med Informat Team, Biomed Res Fdn, Athens 11527, Greece

来源：

CANCER LETTERS | 2011年 / 300卷 / 01期

关键词：

Lung cancer; p73; DNA methylation; Delta Np73; TAp73; CPG-ISLAND METHYLATION; P73; GENE; POOR-PROGNOSIS; P53; FAMILY; EXPRESSION; CARCINOGENESIS; NEUROBLASTOMA; LYMPHOMAS; PATTERNS;

D O I：

10.1016/j.canlet.2010.09.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

p73 possesses an extrinsic P1 promoter and an intrinsic P2 promoter controlling the expression of the pro-apoptotic TAp73 isoforms and the anti-apoptotic Delta Np73 isoforms respectively In this study we investigated the DNA methylation status of both promoters as a means of epigenetic transcriptional control of their corresponding isoforms in 102 primary non-small cell lung carcinomas (NSCLCs) We demonstrated that while P1 hypermethylation-associated reduction of TAp73 mRNA levels is relatively infrequent the P2 hypomethylation-associated over-expression of Delta Np73 mRNA is a frequent event particularly among squamous cell carcinomas P2 hypomethylation strongly correlated with LINE-1 element hypomethylation indicating that Delta Np73 over-expression may be a passive consequence of global DNA hypomethylation (c) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：79 / 86

页数：8

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