Preparation of ethyl 5-iodo-1H-indole-2-carboxylate

被引：7

作者：

Beshore, DC ^{[1
]}

Dinsmore, CJ ^{[1
]}

机构：

[1] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA

来源：

SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 14期

关键词：

indole; regioselective halogenation; dehalogenation;

D O I：

10.1081/SCC-120021830

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile, two step procedure for the preparation of ethyl 5-iodo-1H-indole-2-carboxylate (1) from commercially available ethyl 1H-indole-2-carboxylate is described herein, employing a regioselective C3, C5-bisiodination followed by zinc-mediated C3-dehalogenation.

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页码：2423 / 2427

页数：5

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