Molecular Determinants of Radiation Response in Non-Small Cell Lung Cancer

被引：9
作者：
Yom, Sue S. [1 ]
Diehn, Maximilian [2 ,3 ]
Raben, David [4 ]
机构：
[1] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA USA
[2] Stanford Univ, Dept Radiat Oncol, Stanford Canc Inst, Stanford, CA 94305 USA
[3] Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
[4] Univ Colorado Hlth, Dept Radiat Oncol, Aurora, CO 80045 USA
来源：
SEMINARS IN RADIATION ONCOLOGY | 2015年 / 25卷 / 02期
关键词：
GROWTH-FACTOR RECEPTOR; PHASE-I COMBINATION; POLY(ADP-RIBOSE) POLYMERASE; THORACIC RADIATION; CLINICAL-TRIAL; BREAST-CANCER; TGF-BETA; SYNTHETIC LETHALITY; NEGATIVE REGULATION; IONIZING-RADIATION;
D O I：
10.1016/j.semradonc.2014.12.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Non-small cell lung cancers are now recognized to contain considerable heterogeneity and molecular diversity. Substantial progress has been made regarding molecular determinants of response to targeted agents in advanced lung cancer, and recent findings have revealed subsets of patients with driver mutations that respond rapidly to selective inhibitors. In addition, new approaches to disrupting DNA repair and inflammation and activation of the immune system are being explored. A key question in the field is whether therapeutic multimodality options incorporating radiation therapy can capitalize on the gains made in systemic therapy. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：67 / 77
页数：11
相关论文
共 125 条
  • [1] Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer
    Abazeed, Mohamed E.
    Adams, Drew J.
    Hurov, Kristen E.
    Tamayo, Pablo
    Creighton, Chad J.
    Sonkin, Dmitriy
    Giacomelli, Andrew O.
    Du, Charles
    Fries, Daniel F.
    Wong, Kwok-Kin
    Mesirov, Jill P.
    Loeffler, Jay S.
    Schreiber, Stuart L.
    Hammerman, Peter S.
    Meyerson, Matthew
    [J]. CANCER RESEARCH, 2013, 73 (20) : 6289 - 6298
  • [2] Tumor-Specific Cytotoxic T Cells Are Crucial for Efficacy of Immunomodulatory Antibodies in Patients with Lung Cancer
    Aerts, Joachim G.
    Hegmans, Joost P.
    [J]. CANCER RESEARCH, 2013, 73 (08) : 2381 - 2388
  • [3] Inhibition of poly (ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models
    Albert, Jeffrey M.
    Cao, Carolyn
    Kim, Kwang Woon
    Willey, Christopher D.
    Geng, Ling
    Xiao, Dakai
    Wang, Hong
    Sandler, Alan
    Johnson, David H.
    Colevas, Alexander D.
    Low, Jennifer
    Rothenberg, Mace L.
    Lu, Bo
    [J]. CLINICAL CANCER RESEARCH, 2007, 13 (10) : 3033 - 3042
  • [4] Randomized Phase III Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III to IV Head and Neck Carcinoma: RTOG 0522
    Ang, K. Kian
    Zhang, Qiang
    Rosenthal, David I.
    Nguyen-Tan, Phuc Felix
    Sherman, Eric J.
    Weber, Randal S.
    Galvin, James M.
    Bonner, James A.
    Harris, Jonathan
    El-Naggar, Adel K.
    Gillison, Maura L.
    Jordan, Richard C.
    Konski, Andre A.
    Thorstad, Wade L.
    Trotti, Andy
    Beitler, Jonathan J.
    Garden, Adam S.
    Spanos, William J.
    Yom, Sue S.
    Axelrod, Rita S.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) : 2940 - +
  • [5] [Anonymous], J CLIN ONCOL S
  • [6] Targeting the TGF-β1 Pathway to Prevent Normal Tissue Injury After Cancer Therapy
    Anscher, Mitchell S.
    [J]. ONCOLOGIST, 2010, 15 (04) : 350 - 359
  • [7] Antitransforming growth factor-β antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation
    Anscher, MS
    Thrasher, B
    Rabbani, Z
    Teicher, B
    Vujaskovic, Z
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2006, 65 (03): : 876 - 881
  • [8] The Clinical Development of Molecularly Targeted Agents in Combination With Radiation Therapy: A Pharmaceutical Perspective
    Ataman, Ozlem U.
    Sambrook, Sally J.
    Wilks, Chris
    Lloyd, Andrew
    Taylor, Amanda E.
    Wedge, Stephen R.
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 84 (04): : E447 - E454
  • [9] Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
    Audeh, M. William
    Carmichael, James
    Penson, Richard T.
    Friedlander, Michael
    Powell, Bethan
    Bell-McGuinn, Katherine M.
    Scott, Clare
    Weitzel, Jeffrey N.
    Oaknin, Ana
    Loman, Niklas
    Lu, Karen
    Schmutzler, Rita K.
    Matulonis, Ursula
    Wickens, Mark
    Tutt, Andrew
    [J]. LANCET, 2010, 376 (9737) : 245 - 251
  • [10] Molecular Profiling to Optimize Treatment in Non-Small Cell Lung Cancer: A Review of Potential Molecular Targets for Radiation Therapy by the Translational Research Program of the Radiation Therapy Oncology Group
    Ausborn, Natalie L.
    Quynh Thu Le
    Bradley, Jeffrey D.
    Choy, Hak
    Dicker, Adam P.
    Saha, Debabrata
    Simko, Jeff
    Story, Michael D.
    Torossian, Artour
    Lu, Bo
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 83 (04): : E453 - E464
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