Strain-Related Differences in the Immune Response: Relevance to Human Stroke

被引：48

作者：

Becker, Kyra J. ^{[1
]}

机构：

[1] Univ Washington, Dept Neurol, Harborview Med Ctr, Sch Med, 325 9th Ave,Box 359775, Seattle, WA 98104 USA

来源：

TRANSLATIONAL STROKE RESEARCH | 2016年 / 7卷 / 04期

关键词：

Stroke; Immunology; EAE; Strain; Immune response; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; FOCAL CEREBRAL-ISCHEMIA; INDUCED DEMYELINATING DISEASE; VASCULAR ENDOTHELIAL-CELLS; AGE-RELATED-CHANGES; RAT STRAIN; MULTIPLE-SCLEROSIS; ALPHA-4; INTEGRIN;

D O I：

10.1007/s12975-016-0455-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There are significant differences in the immune response and in the susceptibility to autoimmune diseases among rodent strains. It would thus be expected that the contribution of the immune response to cerebral ischemic injury would also differ among rodent strains. More importantly, there are significant differences between the immune responses of rodents and humans. All of these factors are likely to impact the successful translation of immunomodulatory therapies from experimental rodent models to patients with stroke.

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页码：303 / 312

页数：10

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