Restricted access media supports for direct high-throughput analysis of biological fluid samples: review of recent applications

被引：31
作者：
Cassiano, Neila Maria [1 ]
Barreiro, Juliana Cristina [1 ]
Moraes, Marcela Cristina [1 ]
Oliveira, Regina Vincenzi [1 ]
Cass, Quezia Bezerra [1 ]
机构：
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil
来源：
BIOANALYSIS | 2009年 / 1卷 / 03期
基金：
巴西圣保罗研究基金会;
关键词：
PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE MICROEXTRACTION; MOLECULARLY IMPRINTED POLYMER; TANDEM MASS-SPECTROMETRY; HPLC-MS/MS METHOD; MEASURING ENVIRONMENTAL PHENOLS; MONOLITHIC STATIONARY PHASES; MULTIDIMENSIONAL ONLINE SPE; DIRECT-INJECTION ANALYSIS; COLUMN-SWITCHING LC;
D O I：
10.4155/BIO.09.39
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
This review presents an update on the use of restricted-access materials (RAMs) for direct injection of biological samples. The fundamental improvements in the preparation of tailored RAMs and the diversity of applications with these phases are presented. Insights into diminishing the matrix effect by the use of RAM supports in methods by LC-MS and into the low number of methods for enantiomeric separations by direct injections of biological samples are addressed. The diversity of systems that incorporate RAMs for selective sample clean-up or fractionation in proteome and peptidome analysis is also covered.
引用
收藏
页码：577 / 594
页数：18
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