Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors

被引：32

作者：

Pfefferkorn, Jeffrey A. ^{[1
]}

Choi, Chulho ^{[1
]}

Song, Yuntao ^{[1
]}

Trivedi, Bharat K. ^{[1
]}

Larsen, Scott D. ^{[1
]}

Askew, Valerie ^{[1
]}

Dillon, Lisa ^{[1
]}

Hanselman, Jeffrey C. ^{[1
]}

Lin, Zhiwu ^{[1
]}

Lu, Gina ^{[1
]}

Robertson, Andrew ^{[1
]}

Sekerke, Catherine ^{[1
]}

Auerbach, Bruce ^{[1
]}

Pavlovsky, Alexander ^{[1
]}

Harris, Melissa S. ^{[1
]}

Bainbridge, Graeme ^{[1
]}

Caspers, Nicole ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Michigan Labs, Ann Arbor, MI 48105 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 16期

关键词：

HMG-CoA reductase inhibitor; statin; Hypercholesterolemia;

D O I：

10.1016/j.bmcl.2007.05.097

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using structure-based design, a novel series of conformationally restricted, pyrrole-based inhibitors of HMG-CoA reductase were discovered. Leading analogs demonstrated potent inhibition of cholesterol synthesis in both in vitro and in vivo models and may be useful for the treatment of hypercholesterolemia and related lipid disorders. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4531 / 4537

页数：7

共 20 条

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