Seizing upon Mechanisms for Impaired Consciousness

被引：3
作者：
Farzampour, Zoya [1 ,2 ]
Huguenard, John [1 ,2 ]
机构：
[1] Stanford Univ, Sch Med, Stanford Neurosci Program, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
来源：
NEURON | 2015年 / 85卷 / 03期
关键词：
TEMPORAL-LOBE EPILEPSY; SEIZURES; SPECT;
D O I：
10.1016/j.neuron.2015.01.023
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Transient loss of consciousness associated with focal temporal lobe seizures is a complex phenomenon with life-threatening repercussions. In this issue of Neuron, Motelow et al. (2015) describe decreased cholinergic drive and suppressed subcortical arousal in seizures as a novel mechanism for impaired cortical function.
引用
收藏
页码：453 / 455
页数：3
相关论文
共 15 条
[1]   Ictal neocortical slowing in temporal lobe epilepsy [J].
Blumenfeld, H ;
Rivera, M ;
McNally, KA ;
Davis, K ;
Spencer, DD ;
Spencer, SS .
NEUROLOGY, 2004, 63 (06) :1015-1021
[2]   Positive and negative network correlations in temporal lobe epilepsy [J].
Blumenfeld, H ;
McNally, KA ;
Vanderhill, SD ;
Paige, AL ;
Chung, R ;
Davis, K ;
Norden, AD ;
Stokking, R ;
Studholme, C ;
Novotny, EJ ;
Zubal, IG ;
Spencer, SS .
CEREBRAL CORTEX, 2004, 14 (08) :892-902
[3]   SPONTANEOUS FIRING PATTERNS AND AXONAL PROJECTIONS OF SINGLE CORTICOSTRIATAL NEURONS IN THE RAT MEDIAL AGRANULAR CORTEX [J].
COWAN, RL ;
WILSON, CJ .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 71 (01) :17-32
[4]   Remote effects of focal hippocampal seizures on the rat neocortex [J].
Englot, Dario J. ;
Mishra, Asht M. ;
Mansuripur, Peter K. ;
Herman, Peter ;
Hyder, Fahmeed ;
Blumenfeld, Hal .
JOURNAL OF NEUROSCIENCE, 2008, 28 (36) :9066-9081
[5]   Cortical Deactivation Induced by Subcortical Network Dysfunction in Limbic Seizures [J].
Englot, Dario J. ;
Modi, Badri ;
Mishra, Asht M. ;
DeSalvo, Matthew ;
Hyder, Fahmeed ;
Blumenfeld, Hal .
JOURNAL OF NEUROSCIENCE, 2009, 29 (41) :13006-13018
[6]  
Gummadavelli A., 2014, Epilepsia
[7]   Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition [J].
Haider, B ;
Duque, A ;
Hasenstaub, AR ;
McCormick, DA .
JOURNAL OF NEUROSCIENCE, 2006, 26 (17) :4535-4545
[8]   Awareness and responsiveness during partial seizures [J].
Inoue, Y ;
Mihara, T .
EPILEPSIA, 1998, 39 :7-10
[9]   Pathophysiology of altered consciousness during seizures - Subtraction SPECT study [J].
Lee, KH ;
Meador, KJ ;
Park, YD ;
King, DW ;
Murro, AM ;
Pillai, JJ ;
Kaminski, RJ .
NEUROLOGY, 2002, 59 (06) :841-846
[10]   ROLE OF THE FRONTAL LOBES IN THE PROPAGATION OF MESIAL TEMPORAL-LOBE SEIZURES [J].
LIEB, JP ;
DASHEIFF, RM ;
ENGEL, J .
EPILEPSIA, 1991, 32 (06) :822-837
12