Ovarian Cancer The Role of Functional Imaging as an End Point in Clinical Trials

被引：2

作者：

Sala, Evis ^{[1
]}

DeSouza, Nandita ^{[2
,3
]}

Lee, Susanna I. ^{[4
]}

Atri, Mostafa ^{[5
]}

Hricak, Hedvig ^{[6
]}

机构：

[1] Addenbrookes Hosp, Dept Radiol, Cambridge CB2 0QQ, England

[2] Inst Canc Res, Surrey, England

[3] Royal Marsden Hosp, Surrey, England

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA

[5] Univ Toronto, Abdominal Div, Toronto, ON M5S 1A1, Canada

[6] Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10021 USA

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | 2010年 / 20卷 / 06期

关键词：

Ovarian cancer; Functional imaging; Biomarker; Clinical trial; APPARENT DIFFUSION-COEFFICIENT; POSITRON-EMISSION-TOMOGRAPHY; DIAGNOSTIC ONCOLOGY GROUP; CONTRAST-ENHANCED MRI; COMPUTED-TOMOGRAPHY; PET-CT; PERITONEAL CARCINOMATOSIS; NEOADJUVANT CHEMOTHERAPY; 2ND-LOOK LAPAROTOMY; PREDICTING RESPONSE;

D O I：

10.1111/IGC.0b013e3181e0a353

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Gynaecological Cancer InterGroup conducts collaborative trials in gynecologic cancer and also aims to develop standards that can be used to strengthen all aspects of study methodology. There is an urgent need to develop more refined imaging end points that can be used as early treatment response biomarkers in ovarian cancer. Therefore, the Gynaecological Cancer InterGroup commissioned an expert position paper on the role of functional imaging as an end point in clinical trials in ovarian cancer. In this position paper, we state the limitation of current anatomical imaging methods used in clinical trials, highlight the potential of functional imaging, and provide key recommendations on the use of functional imaging as an end point in ovarian cancer clinical trials.

引用

页码：971 / 978

页数：8

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