Isocyanide-Based Multicomponent Reaction To Furnish N-Functionalized Indoles by using N-Acyliminium Ions as Key Intermediates

被引：4

作者：

Cheng, Guangsheng ^{[1
]}

Deng, Hongmei ^{[2
]}

He, Xiang ^{[1
]}

Gao, Yu ^{[3
]}

Li, Chunju ^{[1
]}

Jia, Xueshun ^{[1
]}

Li, Jian ^{[1
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Shanghai Univ, Instrumental Anal & Res Ctr, Lab Microstruct, Shanghai 200444, Peoples R China

[3] China Pharmaceut Univ, Dept Pharm, Nanjing 211198, Jiangsu, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 30期

基金：

中国国家自然科学基金;

关键词：

Multicomponent reactions; Isocyanides; Allenes; Nitrogen heterocycles; Zwitterions; CHIRAL PHOSPHORIC-ACID; FRIEDEL-CRAFTS ALKYLATION; ALLYLIC ALKYLATION; SPIROCYCLIC OXINDOLES; MOLECULAR COMPLEXITY; 3-COMPONENT REACTION; POLYCYCLIC SKELETON; TOLUENE DERIVATIVES; INSERTION REACTION; CASCADE REACTION;

D O I：

10.1002/ejoc.201700826

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The present work discloses an efficient multicomponent reaction of isocyanides, allenoates, and indoles. This protocol provides rapid and direct access to N-functionalized indoles from readily available starting materials, in the absence of any catalyst. The strategy also features a broad substrate scope and mild conditions.

引用

页码：4507 / 4510

页数：4

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