The first stereo selective total synthesis of (3R),(5R)-5-hydroxy-de-O-methyllasiodiplodin and its epimer via a RCM protocol

被引：19

作者：

Yadav, J. S. ^{[1
]}

Das, Saibal ^{[1
]}

Reddy, J. Satyanarayana ^{[1
]}

Thrimurtulu, N. ^{[1
]}

Prasad, A. R. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Organ Div 1, Hyderabad 500607, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 31期

关键词：

RING-CLOSING-METATHESIS; CATALYTIC SODIUM TETRAHYDROBORATE; CHELATION-CONTROLLED REDUCTION; DIMETHYL SULFIDE COMPLEX; STEREOSELECTIVE SYNTHESIS; LASIODIPLODIA-THEOBROMAE; EFFICIENT SYNTHESIS; APICULAREN-A; PALLADIUM; ACID;

D O I：

10.1016/j.tetlet.2010.05.115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of (3R),(5R)-5-hydroxy-de-O-methyllasiodiplodin and its epimer is reported from malic acid. The adopted approach is highly convergent and stereoselective. The strategy utilizes syn selective reduction and ring-closing metathesis as key steps. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4050 / 4052

页数：3

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