Breakthrough therapies in B-cell non-Hodgkin lymphoma

被引：33

作者：

Cheah, C. Y. ^{[1
,2
,3
]}

Fowler, N. H. ^{[4
]}

Wang, M. L. ^{[4
]}

机构：

[1] Sir Charles Gairdner Hosp, Dept Haematol, Nedlands, WA 6009, Australia

[2] Pathwest Lab Med WA, Nedlands, WA 6009, Australia

[3] Univ Western Australia, Crawley, Australia

[4] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA

来源：

ANNALS OF ONCOLOGY | 2016年 / 27卷 / 05期

关键词：

lymphomas; treatment; novel agents; ibrutinib; idelalisib; venetoclax; CHRONIC LYMPHOCYTIC-LEUKEMIA; ANTI-CD20; MONOCLONAL-ANTIBODY; IMMUNOCONJUGATE INOTUZUMAB OZOGAMICIN; ADAPTIR(TM) THERAPEUTIC PROTEIN; REFRACTORY FOLLICULAR LYMPHOMA; PHASE-II TRIAL; OBINUTUZUMAB GA101; CLINICAL ACTIVITY; OFATUMUMAB MONOTHERAPY; OPEN-LABEL;

D O I：

10.1093/annonc/mdw029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This comprehensive review provides a detailed analysis of the breakthrough agents in the field, with a focus on recent clinical data. We describe agents targeting the B-cell receptor pathway, Bcl-2 inhibitors, emerging epigenetic therapies, new monoclonal antibodies and antibody drug conjugates, selective inhibitors of nuclear export, PD-1 inhibitors and chimeric antigen receptor T cells.The last 5 years have seen significant advances in our understanding of the molecular pathogenesis of B-cell lymphomas. This has led to the emergence of a large number of new therapeutic agents exploiting precise aspects of the tumor cell's signaling pathways, surface antigens or microenvironment. The purpose of this comprehensive review is to provide a detailed analysis of the breakthrough agents in the field, with a focus on recent clinical data. We describe agents targeting the B-cell receptor pathway, Bcl-2 inhibitors, emerging epigenetic therapies, new monoclonal antibodies and antibody drug conjugates, selective inhibitors of nuclear export, agents targeting the programmed cell death axis and chimeric antigen receptor T cells.

引用

页码：778 / 787

页数：10

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