Nickel-Catalyzed Site-Selective C-H Bond Difluoroalkylation of 8-Aminoquinolines on the C5-Position

被引：98
|
作者：
Chen, Hao [1 ]
Li, Pinhua [1 ]
Wang, Min [1 ]
Wang, Lei [1 ,2 ]
机构：
[1] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China
[2] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 19期
基金：
中国国家自然科学基金;
关键词：
BIDENTATE-CHELATION ASSISTANCE; ARYL BORONIC ACIDS; C(SP(3))-H BONDS; DIRECTING GROUPS; COPPER; FUNCTIONALIZATION; ACTIVATION; QUINOLINES; SULFONYLATION; ALKYLATION;
D O I：
10.1021/acs.orglett.6b02166
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient protocol for nickel-catalyzed regioselective C-H bond difluoroalkylation of 8-aminoquinoline scaffolds with functionalized difluoromethyl bromides was developed. The reaction has broad substrate scope and provides a facile and useful access to the corresponding C5-functionalized difluoromethylated quinolines in good to excellent yields.
引用
收藏
页码：4794 / 4797
页数：4
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