VALIDATION OF TLC - DENSITOMETRIC METHOD FOR DETERMINATION OF GALANTHAMINE HYDROBROMIDE IN PHARMACEUTICAL DOSAGE PREPARATIONS

被引：0
作者：
Tsvetkova, Dobrina [1 ]
Obreshkova, Danka [1 ]
Danchev, Nikolai [2 ]
机构：
[1] Med Univ Sofia, Dept Pharmaceut Chem, Fac Pharm, Sofia 1000, Bulgaria
[2] Med Univ Sofia, Dept Pharmacol & Toxicol, Fac Pharm, Sofia 1000, Bulgaria
来源：
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES | 2011年 / 64卷 / 12期
关键词：
Galanthamine hydrobromide; TLC; densitometry; validation; accuracy; precision; LIQUID-CHROMATOGRAPHY; ELECTROPHORESIS; METABOLITES; URINE; UV;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
TLC - Densitometric method for determination of Galanthamine hydrobromide in pharmaceutical dosage preparations is validated in respect of analytical parameters: selectivity, accuracy, precision and linearity. Accuracy is represented by the values of the degree of recovery (R) over bar [%] +/- RSD (relative standard deviation): 102.47 +/- 1.94 (C-G5); 98.47 +/- 0.7 (C-G10); 100.56 +/- 0.33 (C-G15). Precision is estimated by the uncertainty of the result, determined by SD, RSD and confidence interval (CI, (X) over bar divided by t.S (X) over bar). All data suit relevant CI: 5.09 divided by 5.85 (C-G5); 9.30 divided by 10.06 (C-G10); 15.27 divided by 17.63) (C-G15). An equation: y = 2.10(7).x + 25364 shows the proportional accordance between peak area and concentration, with regression coefficient R-2 = 0.997.
引用
收藏
页码：1689 / 1694
页数：6
相关论文
共 50 条
[41]   Densitometric determination of S-carboxymethylcysteine in syrup, and validation of the method [J].
Indrayanto, G ;
Widjaja, S ;
Aditama, L ;
Darmawan, L .
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, 1998, 11 (04) :263-266
[42]   APPLICATION OF A STABILITY-INDICATING TLC METHOD FOR THE QUANTITATIVE DETERMINATION OF DEXKETOPROFEN TROMETAMOL IN PHARMACEUTICAL DOSAGE FORMS [J].
Bhusari, Vidhya K. ;
Dhaneshwar, Sunil R. .
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2011, 34 (20) :2606-2620
[43]   VOLTAMMETRIC DETERMINATION OF ZINC IN COMPOUND PHARMACEUTICAL PREPARATIONS - VALIDATION OF METHOD [J].
Lutka, Anna ;
Bukowska, Honorata .
ACTA POLONIAE PHARMACEUTICA, 2009, 66 (05) :471-475
[44]   vOLTAMMETRIC DETERMINATION OF COPPER IN SELECTED PHARMACEUTICAL PREPARATIONS - VALIDATION OF THE METHOD [J].
Lutka, Anna ;
Maruszewska, Malgorzata .
ACTA POLONIAE PHARMACEUTICA, 2011, 68 (02) :179-184
[45]   SPE/TLC/Densitometric Quantification of Selected Synthetic Food Dyes in Liquid Foodstuffs and Pharmaceutical Preparations [J].
Sobanska, Anna W. ;
Pyzowski, Jaroslaw ;
Brzezinska, Elzbieta .
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY, 2017, 2017
[46]   Sensitive and Cost-Effective TLC-Densitometric Method for Determination of Metronidazole and Tinidazole in Tablets [J].
Pyka-Pajak, Alina .
PROCESSES, 2024, 12 (04)
[47]   VALIDATION OF TLC DENSITOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF L-LEUCINE AND L-VALINE IN ADDITIVES [J].
Ivanov, Kalin ;
Tsvetkova, Dobrina ;
Obreshkova, Danka .
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES, 2011, 64 (10) :1429-1434
[48]   Validated RP-TLC Method with Densitometry for Assay of Finasteride in Simple Pharmaceutical Dosage Form [J].
Dolowy, Malgorzata ;
Piontek, Agata ;
Pyka-Pajak, Alina .
CURRENT PHARMACEUTICAL ANALYSIS, 2018, 14 (03) :298-305
[49]   Densitometric Determination of Betamethasone Dipropionate and Salicylic Acid in Lotions, and Validation of the Method [J].
Listyo Wulandari ;
Gunawan Indrayanto .
JPC – Journal of Planar Chromatography – Modern TLC, 2003, 16 :438-441
[50]   DENSITOMETRIC DETERMINATION OF CONJUGATED ESTROGENS IN THE RAW-MATERIAL AND IN PHARMACEUTICAL PREPARATIONS [J].
NOVAKOVIC, J ;
AGBABA, D ;
VLADIMIROV, S ;
ZIVANOVSTAKIC, D .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1990, 8 (03) :253-257
12345