VALIDATION OF TLC - DENSITOMETRIC METHOD FOR DETERMINATION OF GALANTHAMINE HYDROBROMIDE IN PHARMACEUTICAL DOSAGE PREPARATIONS

被引：0
|
作者：
Tsvetkova, Dobrina [1 ]
Obreshkova, Danka [1 ]
Danchev, Nikolai [2 ]
机构：
[1] Med Univ Sofia, Dept Pharmaceut Chem, Fac Pharm, Sofia 1000, Bulgaria
[2] Med Univ Sofia, Dept Pharmacol & Toxicol, Fac Pharm, Sofia 1000, Bulgaria
来源：
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES | 2011年 / 64卷 / 12期
关键词：
Galanthamine hydrobromide; TLC; densitometry; validation; accuracy; precision; LIQUID-CHROMATOGRAPHY; ELECTROPHORESIS; METABOLITES; URINE; UV;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
TLC - Densitometric method for determination of Galanthamine hydrobromide in pharmaceutical dosage preparations is validated in respect of analytical parameters: selectivity, accuracy, precision and linearity. Accuracy is represented by the values of the degree of recovery (R) over bar [%] +/- RSD (relative standard deviation): 102.47 +/- 1.94 (C-G5); 98.47 +/- 0.7 (C-G10); 100.56 +/- 0.33 (C-G15). Precision is estimated by the uncertainty of the result, determined by SD, RSD and confidence interval (CI, (X) over bar divided by t.S (X) over bar). All data suit relevant CI: 5.09 divided by 5.85 (C-G5); 9.30 divided by 10.06 (C-G10); 15.27 divided by 17.63) (C-G15). An equation: y = 2.10(7).x + 25364 shows the proportional accordance between peak area and concentration, with regression coefficient R-2 = 0.997.
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页码：1689 / 1694
页数：6
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