SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 5-AMINO-2-MERCAPTO-1,3,4-THIADIAZOLE DERIVATIVES THIOETERS AND SCHIFF BASES

被引：0

作者：

Rad, Oana ^{[1
]}

Tibor, Rozsa ^{[1
]}

Duma, Mihaela ^{[2
]}

Vlase, Laurian ^{[3
]}

Pirnau, Adrian ^{[4
]}

Tiperciuc, Brindusa ^{[1
]}

Ionut, Ioana ^{[1
]}

Oniga, Ovidiu ^{[1
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmaceut Chem, 41 Victor Babes St, Cluj Napoca 400012, Romania

[2] State Vet Lab Anim Hlth & Food Safety, Cluj Napoca 400572, Romania

[3] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmaceut Technol & Biopharmaceut, Fac Pharm, 41 Victor Babes St, Cluj Napoca 400012, Romania

[4] Natl Inst Res & Dev Isotop & Mol Technol, 1 Donath St, Cluj Napoca, Romania

来源：

STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA | 2016年 / 61卷 / 01期

关键词：

1,3,4-thiadiazole; antibacterial activity; antifungal activity; BIOLOGICAL EVALUATION; HETEROCYCLES;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Starting from 5-amino-2-mercapto-1,3,4-thiadiazole, 23 compounds, Schiff bases and S-mercapto-substituted derivatives, were synthesized. Their structural elucidation was based on elemental analysis, mass spectrometry and proton nuclear magnetic resonance spectroscopy (H-1 NMR). The screening of the antimicrobial activity of the title compounds was realized using the diffusimetric method against several strains of Gram-positive and Gram-negative bacteria and one fungal strain (Candida albicans). Some of the molecules showed moderate to good antibacterial activity against Gramnegative (S. typhimurium, E. coli) and better activity against Gram-positive (B. cereus, L. monocytogenes, S. aureus) bacterial strains. All compounds exhibited moderate to very good activity against C. albicans. Qualitative relationships (SAR) were also established between the chemical structures and the antimicrobial activity of these compounds.

引用

页码：17 / 32

页数：16

共 32 条

[11]

El-Sayed A. T., 2010, EUROPEAN J CHEM, V1, P6

[12] Creeping baselines and adaptive resistance to antibiotics [J].

Fernandez, Lucia ;

Breidenstein, Elena B. M. ;

Hancock, Robert E. W. .

DRUG RESISTANCE UPDATES, 2011, 14 (01) :1-21

[13] Synthesis and biological evaluation of 2-trifluoromethyl/sulfonamido-5,6-diaryl substituted imidazo[2,1-b]-1,3,4-thiadiazoles:: A novel class of cyclooxygenase-2 inhibitors [J].

Gadad, Andanappa K. ;

Palkar, Mahesh B. ;

Arland, K. ;

Noolvi, Malleshappa N. ;

Boreddy, Thippeswamy S. ;

Wagwade, J. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (01) :276-283

[14]

Geeta Mishra Geeta Mishra, 2011, International Journal of ChemTech Research, V3, P1380

[15]

Gupta JK, 2010, MEDICHEMONLINE, V1, P1

[16] Synthesis and antibacterial activity of nitroaryl thiadiazole-gatifloxacin hybrids [J].

Jazayeri, Seyyedehsamira ;

Moshafi, Mohammad Hassan ;

Firoupour, Loghman ;

Emami, Saeed ;

Rajabalian, Saeed ;

Haddad, Mitra ;

Pahlavanzadeh, Farahnaz ;

Esnaashari, Manzarbanoo ;

Shafiee, Abbas ;

Foroumadi, Alireza .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (03) :1205-1209

[17]

Jindal A., 2012, ASIAN J PHARM CLIN R, V5, P199

[18]

Kamotra P, 2007, INDIAN J CHEM B, V46, P980

[19]

Kushwaha N., 2012, Int. J. ChemTech. Res, V4, P517

[20] Discovering new antimicrobial agents [J].

Moellering, Robert C., Jr. .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 37 (01) :2-9

← 1 2 3 4 →