Do disparate mechanisms of duplication add similar genes to the genome?

被引：73

作者：

Davis, JC ^{[1
]}

Petrov, DA ^{[1
]}

机构：

[1] Stanford Univ, Dept Biol Sci, Stanford, CA 90305 USA

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 10期

关键词：

D O I：

10.1016/j.tig.2005.07.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gene duplication is the fundamental source of new genes. Biases in duplication have profound implications for the dynamics of gene content during evolution. In this article, we compare genes arising from whole gene duplication (WGD), smaller scale duplication (SSD) and singletons in Saccharomyces cerevisiae. Our results demonstrate that genes duplicated by WGD and SSD are similarly biased with respect to codon bias and evolutionary rate, although differing significantly in their functional constituency.

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页码：548 / 551

页数：4

相关论文

共 31 条

[1] FatiGO:: a web tool for finding significant associations of Gene Ontology terms with groups of genes [J].

Al-Shahrour, F ;

Díaz-Uriarte, R ;

Dopazo, J .

BIOINFORMATICS, 2004, 20 (04) :578-580

[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[3]

[Anonymous], NOVARTIS FDN S

[4]

Ashburner M, 2002, NOVART FDN SYMP, V247, P66

[5] Preferential duplication of conserved proteins in eukaryotic genomes [J].

Davis, JC ;

Petrov, DA .

PLOS BIOLOGY, 2004, 2 (03) :318-326

[6]

Force A, 1999, GENETICS, V151, P1531

[7] Gene duplication and the structure of eukaryotic genomes [J].

Friedman, R ;

Hughes, AL .

GENOME RESEARCH, 2001, 11 (03) :373-381

[8] Rapid divergence in expression between duplicate genes inferred from microarray data [J].

Gu, ZL ;

Nicolae, D ;

Lu, HHS ;

Li, WH .

TRENDS IN GENETICS, 2002, 18 (12) :609-613

[9] Extent of gene duplication in the genomes of Drosophila, nematode, and yeast [J].

Gu, ZL ;

Cavalcanti, A ;

Chen, FC ;

Bouman, P ;

Li, WH .

MOLECULAR BIOLOGY AND EVOLUTION, 2002, 19 (03) :256-262

[10] THE EVOLUTION OF FUNCTIONALLY NOVEL PROTEINS AFTER GENE DUPLICATION [J].

HUGHES, AL .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1994, 256 (1346) :119-124

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