Hypothyroidism among military infants born in countries of varied iodine nutrition status

被引:5
作者
Cranston, Marcus M. [2 ]
Ryan, Margaret A. K. [3 ]
Smith, Tyler C. [1 ]
Sevick, Carter J. [1 ]
Brodine, Stephanie K. [4 ]
机构
[1] USN, Hlth Res Ctr, San Diego, CA 92152 USA
[2] Keesler Med Ctr, Keesler AFB, MS USA
[3] USN Hosp, Camp Pendleton, CA USA
[4] San Diego State Univ, San Diego, CA 92182 USA
来源
BMC ENDOCRINE DISORDERS | 2010年 / 10卷
关键词
CONGENITAL HYPOTHYROIDISM; URINARY IODINE; UNITED-STATES; SCREENING-PROGRAM; NATIONAL-HEALTH; RISK-FACTORS; PREVALENCE; PREGNANCY;
D O I
10.1186/1472-6823-10-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Iodine deficiency is a global problem representing the most common preventable cause of mental retardation. Recently, the impact of subtle deficiencies in iodine intake on children and pregnant women has been questioned. This study was designed to compare hypothyroidism among infants born to US military families in countries of varied iodine nutrition status. Methods: A cohort design was used to analyze data from the Department of Defense Birth and Infant Health Registry for infants born in 2000-04 (n = 447,691). Hypothyroidism was defined using ICD-9-CM codes from the first year of life (n = 698). The impact of birth location on hypothyroidism was assessed by comparing rates in Germany, Japan, and US territories with the United States, while controlling for infant gender, plurality, gestational age, maternal age, maternal military status, and military parent's race/ethnicity. Results: Hypothyroidism did not vary by birth location with adjusted odds ratios (OR) as follows: Germany (OR 0.82, [95% CI 0.50, 1.35]), Japan (OR 0.67, [95% CI 0.37, 1.22]), and US territories (OR 1.29, [95% CI 0.57, 2.89]). Hypothyroidism was strongly associated with preterm birth (OR 5.44, [95% CI 4.60, 6.42]). Hypothyroidism was also increased among infants with civilian mothers (OR 1.24, [95% CI 1.00, 1.54]), and older mothers, especially ages 40 years and older (OR 2.09, [95% CI 1.33, 3.30]). Conclusions: In this study, hypothyroidism in military-dependent infants did not vary by birth location, but was associated with other risk factors, including preterm birth, civilian maternal status, and advanced maternal age.
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页数:6
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