Treatment of hirsutism with combined pill containing drospirenone

被引：12

作者：

Gregoriou, Odisseas ^{[1
]}

Papadias, Kostantinos ^{[1
]}

Konidaris, Sokratis ^{[1
]}

Bakalianou, Kostantina ^{[1
]}

Salakos, Nikolaos ^{[1
]}

Vrachnis, Nikolaos ^{[1
]}

Creatsas, George ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Aretaie Hosp, Dept Obstet & Gynecol 2, Athens 11528, Greece

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2008年 / 24卷 / 04期

关键词：

hirsutism; hyperandrogenism; drospirenone; ethinyl estradiol; combined oral contraceptive;

D O I：

10.1080/09513590801948309

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the present study was to evaluate the biochemical and clinical effects of the combined pill consisting of ethinyl estradiol (EE) and drospirenone (DRSP) in hirsute patients. Fifty-two adolescents or young women from Greece were treated with 30 mu g EE and 3 mg DRSP for I year. Hirsutism was evaluated by the Ferriman-Gallway (FG) score in the initial visit and at 3, 6 and 12 months. Follicle-stimulating hormone, luteinizing hormone, etradiol, free and total testosterone (T), sex hormone-binding globulin (SHBG), androstenedione and dehydroepiandrosterone sulfate were determined at the same intervals. Hirsutism improved and FG scores reduced to 77.4%, 67.2% and 51.8% at 3, 6 and 12 months, respectively. Plasma SHBG levels rose, while free and total T levels reduced from the third month onwards. In conclusion, the EE/DRSP pill improves hirsutism in women via antiandrogenic and antimineralocorticoid action. The biochemical manifestations of hyperandrogenism are also improved.

引用

页码：220 / 223

页数：4

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