Antigenic Relatedness of Norovirus GII.4 Variants Determined by Human Challenge Sera

被引：12

作者：

Dai, Ying-Chun ^{[1
,3
]}

Zhang, Xu-Fu ^{[2
,3
]}

Xia, Ming ^{[3
]}

Tan, Ming ^{[3
,4
]}

Quigley, Christina ^{[3
]}

Lei, Wen ^{[3
]}

Fang, Hao ^{[3
]}

Zhong, Weiming ^{[3
]}

Lee, Bonita ^{[5
,6
]}

Pang, Xiaoli ^{[5
,6
]}

Nie, Jun ^{[1
]}

Jiang, Xi ^{[3
,4
]}

机构：

[1] Southern Med Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, Guangzhou, Guangdong, Peoples R China

[2] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China

[3] Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA

[4] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA

[5] Prov Lab Publ Hlth ProvLab, Edmonton, AB, Canada

[6] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada

来源：

PLOS ONE | 2015年 / 10卷 / 04期

基金：

美国食品与农业研究所; 美国国家卫生研究院; 中国国家自然科学基金;

关键词：

BLOOD GROUP ANTIGENS; CAPSID PROTEIN FORMS; UNITED-STATES; STRUCTURAL BASIS; ACUTE GASTROENTERITIS; BINDING SPECIFICITY; P-DOMAIN; OUTBREAKS; STRAIN; RECOGNITION;

D O I：

10.1371/journal.pone.0124945

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The GII.4 noroviruses (NoVs) are a single genotype that is responsible for over 50% of NoV gastroenteritis epidemics worldwide. However, GII.4 NoVs have been found to undergo antigenic drifts, likely selected by host herd immunity, which raises an issue for vaccine strategies against NoVs. We previously characterized GII.4 NoV antigenic variations and found significant levels of antigenic relatedness among different GII.4 variants. Further characterization of the genetic and antigenic relatedness of recent GII.4 variants (2008b and 2010 cluster) was performed in this study. The amino acid sequences of the receptor binding interfaces were highly conserved among all GII.4 variants from the past two decades. Using serum samples from patients enrolled in a GII.4 virus challenge study, significant cross-reactivity between major GII.4 variants from 1998 to 2012 was observed using enzyme-linked immunosorbent assays and HBGA receptor blocking assays. The overall abilities of GII.4 NoVs to bind to the A/B/H HBGAs were maintained while their binding affinities to individual ABH antigens varied. These results highlight the importance of human HBGAs in NoV evolution and how conserved antigenic types impact vaccine development against GII.4 variants.

引用

页数：16

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