Scaffolds for bone healing: Concepts, materials and evidence

被引：224
作者：
Lichte, P. [1 ]
Pape, H. C. [1 ]
Pufe, T. [3 ]
Kobbe, P. [1 ]
Fischer, H. [2 ]
机构：
[1] Univ Hosp RWTH Aachen, Dept Trauma Surg, Aachen, Germany
[2] Univ Hosp RWTH Aachen, Dept Dent Mat & Biomat Res, Aachen, Germany
[3] Univ Hosp RWTH Aachen, Dept Anat & Cell Biol, Aachen, Germany
来源：
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 2011年 / 42卷 / 06期
关键词：
Bone defect; Bone healing; Synthetic scaffold; Calcium Phosphate ceramic; Polymer scaffold; Rapid prototyping; MARROW STROMAL CELLS; MESENCHYMAL STEM-CELLS; IN-VITRO; MORPHOGENETIC PROTEINS; EXTRACELLULAR-MATRIX; GENE-EXPRESSION; DIFFERENTIATION; REPAIR; HYDROXYAPATITE; RECONSTRUCTION;
D O I：
10.1016/j.injury.2011.03.033
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Critical sized bone defects have to be filled with material to allow bone healing. The golden standard for this treatment is autogenous bone grafting. Because of donor size morbidity, equivalent synthetic bone scaffolds should be developed. Different materials, especially ceramics and polymers are in the focus of research. Calcium phosphate ceramics show similar properties to bone and are degradable. Different modifications can improve the bioactive features. This article gives an overview about the current materials and their evidence of clinical use. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：569 / 573
页数：5
相关论文
共 48 条
[1]   Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect [J].
Arinzeh, TL ;
Peter, SJ ;
Archambault, MP ;
van den Bos, C ;
Gordon, S ;
Kraus, K ;
Smith, A ;
Kadiyala, S .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2003, 85A (10) :1927-1935
[2]   Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy [J].
Banfi, A ;
Muraglia, A ;
Dozin, B ;
Mastrogiacomo, M ;
Cancedda, R ;
Quarto, R .
EXPERIMENTAL HEMATOLOGY, 2000, 28 (06) :707-715
[3]   Replicative aging and gene expression in long-term cultures of human bone marrow stromal cells [J].
Banfi, A ;
Bianchi, G ;
Notaro, R ;
Luzzatto, L ;
Cancedda, R ;
Quarto, R .
TISSUE ENGINEERING, 2002, 8 (06) :901-910
[4]   De novo reconstruction of functional bone by tissue engineering in the metatarsal sheep model [J].
Bensaïd, W ;
Oudina, K ;
Viateau, V ;
Potier, E ;
Bousson, V ;
Blanchat, C ;
Sedel, L ;
Guillemin, G ;
Petite, H .
TISSUE ENGINEERING, 2005, 11 (5-6) :814-824
[5]   3D printing of bone substitute implants using calcium phosphate and bioactive glasses [J].
Bergmann, Christian ;
Lindner, Markus ;
Zhang, Wen ;
Koczur, Karolina ;
Kirsten, Armin ;
Telle, Rainer ;
Fischer, Horst .
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, 2010, 30 (12) :2563-2567
[6]   Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation:: a review [J].
Böstman, O ;
Pihlajamäki, H .
BIOMATERIALS, 2000, 21 (24) :2615-2621
[7]   FOREIGN-BODY REACTIONS TO FRACTURE FIXATION IMPLANTS OF BIODEGRADABLE SYNTHETIC-POLYMERS [J].
BOSTMAN, O ;
HIRVENSALO, E ;
MAKINEN, J ;
ROKKANEN, P .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1990, 72 (04) :592-596
[8]   Tissue restoration after resorption of polyglycolide and poly-laevo-lactic acid screws [J].
Böstman, OM ;
Laitinen, OM ;
Tynninen, O ;
Salminen, ST ;
Pihlajamäki, HK .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2005, 87B (11) :1575-1580
[9]   Osteogenic differentiation of human mesenchymal stem cells on poly(ethylene glycol)-variant biomaterials [J].
Briggs, Tonye ;
Treiser, Matthew D. ;
Holmes, Paul F. ;
Kohn, Joachim ;
Moghe, Prabhas V. ;
Arinzeh, Treena Livingston .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2009, 91A (04) :975-984
[10]   Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells [J].
Bruder, SP ;
Kurth, AA ;
Shea, M ;
Hayes, WC ;
Jaiswal, N ;
Kadiyala, S .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1998, 16 (02) :155-162
12345