Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10

被引：9

作者：

Yamaji, K ^{[1
]}

Ikegami, H ^{[1
]}

Fujisawa, T ^{[1
]}

Noso, S ^{[1
]}

Nojima, K ^{[1
]}

Babaya, N ^{[1
]}

Itoi-Babaya, M ^{[1
]}

Makino, S ^{[1
]}

Sakamoto, T ^{[1
]}

Ogihara, T ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Geriatr Med, Osaka, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 331卷 / 02期

关键词：

type; 1; diabetes; genetic susceptibility; Cd101; Fcgr1; Idd10; congenic mouse; HS mouse; NOD mouse; sequence;

D O I：

10.1016/j.bbrc.2005.04.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Among polygenes conferring susceptibility to type I diabetes in the NOD mouse, Iddlo oil distal chromosome 3 has been shown to be important for disease susceptibility. In this Study, we investigated the candidacy of Fcgr1 and Cd101 for Idd10, by congenic mapping and candidate gene sequencing. Among seven NOD-related strains Studied. the IIS Mouse Was found to possess a recombinant Idd10 interval with the same sequence at Fegr1 as the NOD mouse, but a different sequence at Cdl10 from that in the NOD mouse with 10 amino acid Substitutions. The frequency of type 1 diabetes in NOD mice congenic for IIS hid10 (NOD.IISIdd10) was significantly reduced as compared to that in the NOD Mouse. despite the presence of the identical Fegr1 sequence. These data indicate that IIS mice possess a resistant allele at Idd10, and Suggest that Cd101. but not Fegr1. is responsi tile for the Idd10 effect. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：536 / 542

页数：7

共 37 条

[1] Type 1 diabetes: new perspectives on disease pathogenesis and treatment [J].

Atkinson, MA ;

Eisenbarth, GS .

LANCET, 2001, 358 (9277) :221-229

[2] CD101 is expressed by skin dendritic cells - Role in T-lymphocyte activation [J].

Bagot, M ;

Martinel, I ;

Charue, D ;

Weill, F ;

Boulland, ML ;

Wechsler, J ;

Freeman, GJ ;

Bensussan, A ;

Boumsell, L .

TISSUE ANTIGENS, 1997, 50 (05) :439-448

[3] Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families [J].

Cox, NJ ;

Wapelhorst, B ;

Morrison, VA ;

Johnson, L ;

Pinchuk, L ;

Spielman, RS ;

Todd, JA ;

Concannon, P .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (04) :820-830

[4] A GENOME-WIDE SEARCH FOR HUMAN TYPE-1 DIABETES SUSCEPTIBILITY GENES [J].

DAVIES, JL ;

KAWAGUCHI, Y ;

BENNETT, ST ;

COPEMAN, JB ;

CORDELL, HJ ;

PRITCHARD, LE ;

REED, PW ;

GOUGH, SCL ;

JENKINS, SC ;

PALMER, SM ;

BALFOUR, KM ;

ROWE, BR ;

FARRALL, M ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE, 1994, 371 (6493) :130-136

[5]

FUJISAWA T, 1995, DIABETOLOGIA, V38, P1493

[6] Mouse FcγRI:: identification and functional characterization of five new alleles [J].

Gavin, AL ;

Leiter, EH ;

Hogarth, PM .

IMMUNOGENETICS, 2000, 51 (03) :206-211

[7] THE NOD MOUSE - RECESSIVE DIABETOGENIC GENE IN THE MAJOR HISTOCOMPATIBILITY COMPLEX [J].

HATTORI, M ;

BUSE, JB ;

JACKSON, RA ;

GLIMCHER, L ;

DORF, ME ;

MINAMI, M ;

MAKINO, S ;

MORIWAKI, K ;

KUZUYA, H ;

IMURA, H ;

STRAUSS, WM ;

SEIDMAN, JG ;

EISENBARTH, GS .

SCIENCE, 1986, 231 (4739) :733-735

[8] IDENTIFICATION OF A NEW SUSCEPTIBILITY LOCUS FOR INSULIN-DEPENDENT DIABETES-MELLITUS BY ANCESTRAL HAPLOTYPE CONGENIC MAPPING [J].

IKEGAMI, H ;

MAKINO, S ;

YAMATO, E ;

KAWAGUCHI, Y ;

UEDA, H ;

SAKAMOTO, T ;

TAKEKAWA, K ;

OGIHARA, T .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (04) :1936-1942

[9] MAJOR HISTOCOMPATIBILITY COMPLEX-LINKED DIABETOGENIC GENE OF THE NONOBESE DIABETIC MOUSE - ANALYSIS OF GENOMIC DNA AMPLIFIED BY THE POLYMERASE CHAIN-REACTION [J].

IKEGAMI, H ;

EISENBARTH, GS ;

HATTORI, M .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (01) :18-24

[10]

Ikegami H, 2002, ANN NY ACAD SCI, V958, P325

← 1 2 3 4 →