Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H2O2

被引：9

作者：

Granato, Alisson Silva ^{[1
,2
]}

Amarante, Giovanni Wilson ^{[2
]}

Adrio, Javier ^{[1
,3
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, Dept Quim Organ, Madrid 28049, Spain

[2] Univ Fed Juiz de Fora, Chem Dept, Sao Pedro, Brazil

[3] Univ Autonoma Madrid, Inst Adv Res Chem Sci IAdChem, Madrid 28049, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 19期

关键词：

UREA-HYDROGEN-PEROXIDE; NUCLEOPHILIC ADDITIONS; CATALYZED OXIDATION; SELECTIVE OXIDATION; N-OXIDES; N; N-DISUBSTITUTED HYDROXYLAMINES; FLUORINATED ALCOHOLS; CYCLIC NITRONES; TERTIARY-AMINES; COMPLEXES;

D O I：

10.1021/acs.joc.1c01888

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An environmentally benign protocol for the generation of nitrones from benzylic secondary amines via catalyst-free oxidation of secondary amines using H2O2 in MeOH or CH3CN is described. This methodology provides a selective access to a variety of C-aryl nitrones in yields of 60 to 93%. Several studies have been performed to shed light on the reaction mechanism and the role of the solvent.

引用

页码：13817 / 13823

页数：7

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