Influence of lifestyle factors and staple foods from the Mediterranean diet on non-alcoholic fatty liver disease among older individuals with metabolic syndrome features

被引:33
作者
Bullon-Vela, Vanessa [1 ]
Abete, Itziar [1 ,2 ]
Tur, Josep A. [2 ,3 ]
Pinto, Xavier [2 ,4 ]
Corbella, Emili [2 ,4 ]
Martinez-Gonzalez, Miguel A. [2 ,5 ]
Toledo, Estefania [2 ,5 ]
Corella, Dolores [2 ,6 ]
Macias, Manuel [2 ,7 ]
Tinahones, Francisco [2 ,7 ]
Fito, Montserrat [2 ,8 ]
Estruch, Ramon [2 ,9 ]
Ros, Emilio [2 ,10 ]
Salas-Salvado, Jordi [2 ,11 ]
Daimiel, Lidia [12 ]
Angeles Zulet, M. [1 ,2 ]
Alfredo Martinez, J. [1 ,2 ]
机构
[1] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain
[2] Inst Hlth Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain
[3] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain
[4] Hosp Univ Bellvitge, Internal Med, Lipids & Vasc Risk Unit, Barcelona, Spain
[5] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain
[6] Univ Valencia, Dept Prevent Med, Valencia, Spain
[7] Univ Malaga, Virgen de la Victoria Hosp, Dept Endocrinol, Malaga, Spain
[8] Hosp del Mar Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp CARIN, Barcelona, Spain
[9] Univ Barcelona, Hosp Clin, Dept Internal Med, IDIBAPS, Barcelona, Spain
[10] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain
[11] Rovira & Virgili Univ, Univ Hosp St Joan de Reus, Pere Virgili Inst Hlth Res, Dept Biochem & Biotechnol,Human Nutr Unit, Reus, Spain
[12] UAM, IMDEA Food, Nutr Genom & Epigen Program, CEI,CSIC, Madrid, Spain
基金
欧洲研究理事会;
关键词
NAFLD; Inflammation; Nutrition; Obesity; PHYSICAL-ACTIVITY; GLUCOSE INDEX; HEALTH; TRIGLYCERIDE; STEATOSIS; ADHERENCE; SURVIVAL; OBESITY;
D O I
10.1016/j.nut.2019.110620
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver morbidity. This condition often is accompanied by obesity, diabetes, and metabolic syndrome (MetS). The aim of this study was to evaluate the connection between lifestyle factors and NAFLD in individuals with MetS. Methods: A cross-sectional study with 328 participants (55-75 y of age) diagnosed with MetS participating in the PREDIMED-Plus trial was conducted. NAFLD status was evaluated using the non-invasive hepatic steatosis index (HSI). Sociodemographic, clinical, and dietary data were collected. Adherence to the Mediterranean diet (mainly assessed by the consumption of olive oil, nuts, legumes, whole grain foods, fish, vegetables, fruits, and red wine) and physical activity were assessed using validated questionnaires. Results: Linear regression analyses revealed that HSI values tended to be lower with increasing physical activity tertiles (T2, beta = -1.47; 95% confidence interval [CI], -2.73 to -0.20; T3, beta = -1.93; 95% CI, -3.22 to -0.65 versus T1, P-trend = 0.001) and adherence to the Mediterranean diet was inversely associated with HSI values: (moderate adherence beta = -0.70; 95% CI, -1.92 to 0.53; high adherence beta = -1.57; 95% CI, -3.01 to -0.13 versus lower, P-trend = 0.041). Higher tertiles of legume consumption were inversely associated with the highest tertile of HSI (T2, relative risk ratio [RRR], 0.45; 95% CI, 0.22-0.92; P = 0.028; T3, RRR, 0.48; 95% CI, 0.24-0.97; P = 0.041 versus T1). Conclusion: Physical activity, adherence to the Mediterranean diet, and consumption of legumes were inversely associated with a non-invasive marker of NAFLD in individuals with MetS. This data can be useful in implementing precision strategies aimed at the prevention, monitoring, and management of NAFLD. (C) 2019 Elsevier Inc. All rights reserved.
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页数:8
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