Mitochondrial DNA replication in mammalian cells: overview of the pathway

被引：117

作者：

Falkenberg, Maria ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Med Biochem & Cell Biol, POB 440, S-40530 Gothenburg, Sweden

来源：

MITOCHONDRIAL DISEASES | 2018年 / 62卷 / 03期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

MOUSE L-CELLS; POLYMERASE-GAMMA; TRANSCRIPTION FACTOR; D-LOOP; EMBRYONIC LETHALITY; ACCESSORY SUBUNIT; ESCHERICHIA-COLI; BINDING PROTEIN; RNA-POLYMERASE; KNOCKOUT MICE;

D O I：

10.1042/EBC20170100

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA genome and a dedicated DNA replication machinery is required for its maintenance. Many disease-causing mutations affect mitochondrial replication factors and a detailed understanding of the replication process may help to explain the pathogenic mechanisms underlying a number of mitochondrial diseases. We here give a brief overview of DNA replication in mammalian mitochondria, describing our current understanding of this process and some unanswered questions remaining.

引用

页码：287 / 296

页数：10

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