Optogenetics sheds new light on tissue engineering and regenerative medicine

被引：25
作者：
Hu, Wenzhi [1 ,2 ,3 ]
Li, Qiankun [1 ,2 ,3 ]
Li, Bingmin [1 ,2 ,3 ]
Ma, Kui [2 ,3 ]
Zhang, Cuiping [2 ,3 ]
Fu, Xiaobing [1 ,2 ,3 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Coll Life Sci, Inst Basic Med Sci, Wound Healing & Cell Biol Lab, 28 Fuxing Rd, Beijing 100853, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Fourth Med Ctr, Key Lab Tissue Repair & Regenerat PLA, Beijing 100048, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Fourth Med Ctr, Beijing Key Res Lab Skin Injury, Beijing 100048, Peoples R China
来源：
BIOMATERIALS | 2020年 / 227卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Optogenetics; Tissue engineering; Regenerative medicine; Signaling dynamics; Development; PROTEIN-PROTEIN INTERACTIONS; UP-CONVERSION NANOPARTICLES; RECEPTOR TYROSINE KINASES; GENE-EXPRESSION; OPTICAL CONTROL; SPATIOTEMPORAL CONTROL; DIFFERENTIATION RESPONSES; VERTEBRATE SEGMENTATION; MEDIATED INDUCTION; STRUCTURAL BASIS;
D O I：
10.1016/j.biomaterials.2019.119546
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Optogenetics has demonstrated great potential in the fields of tissue engineering and regenerative medicine, from basic research to clinical applications. Spatiotemporal encoding during individual development has been widely identified and is considered a novel strategy for regeneration. A as a noninvasive method with high spatiotemporal resolution, optogenetics are suitable for this strategy. In this review, we discuss roles of dynamic signal coding in cell physiology and embryonic development. Several optogenetic systems are introduced as ideal optogenetic tools, and their features are compared. In addition, potential applications of optogenetics for tissue engineering are discussed, including light-controlled genetic engineering and regulation of signaling pathways. Furthermore, we present how emerging biomaterials and photoelectric technologies have greatly promoted the clinical application of optogenetics and inspired new concepts for optically controlled therapies. Our summation of currently available data conclusively demonstrates that optogenetic tools are a promising method for elucidating and simulating developmental processes, thus providing vast prospects for tissue engineering and regenerative medicine applications.
引用
收藏
页数：11
相关论文
共 201 条
  • [11] High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels
    Berndt, Andre
    Schoenenberger, Philipp
    Mattis, Joanna
    Tye, Kay M.
    Deisseroth, Karl
    Hegemann, Peter
    Oertner, Thomas G.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (18) : 7595 - 7600
  • [12] X-Optogenetics and U-Optogenetics: Feasibility and Possibilities
    Berry, Rachel
    Getzin, Matthew
    Gjesteby, Lars
    Wang, Ge
    [J]. PHOTONICS, 2015, 2 (01) : 23 - 39
  • [13] Bacteriophytochromes are photochromic histidine kinases using a biliverdin chromophore
    Bhoo, SH
    Davis, SJ
    Walker, J
    Karniol, B
    Vierstra, RD
    [J]. NATURE, 2001, 414 (6865) : 776 - 779
  • [14] The Aspergillus nidulans phytochrome FphA represses sexual development in red light
    Blumenstein, A
    Vienken, K
    Tasler, R
    Purschwitz, J
    Veith, D
    Frankenberg-Dinkel, N
    Fischer, R
    [J]. CURRENT BIOLOGY, 2005, 15 (20) : 1833 - 1838
  • [15] Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
    Boch, Jens
    Scholze, Heidi
    Schornack, Sebastian
    Landgraf, Angelika
    Hahn, Simone
    Kay, Sabine
    Lahaye, Thomas
    Nickstadt, Anja
    Bonas, Ulla
    [J]. SCIENCE, 2009, 326 (5959) : 1509 - 1512
  • [16] Millisecond-timescale, genetically targeted optical control of neural activity
    Boyden, ES
    Zhang, F
    Bamberg, E
    Nagel, G
    Deisseroth, K
    [J]. NATURE NEUROSCIENCE, 2005, 8 (09) : 1263 - 1268
  • [17] Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway
    Bugaj, L. J.
    Sabnis, A. J.
    Mitchell, A.
    Garbarino, J. E.
    Toettcher, J. E.
    Bivona, T. G.
    Lim, W. A.
    [J]. SCIENCE, 2018, 361 (6405)
  • [18] Optogenetic protein clustering and signaling activation in mammalian cells
    Bugaj, Lukasz J.
    Choksi, Atri T.
    Mesuda, Colin K.
    Kane, Ravi S.
    Schaffer, David V.
    [J]. NATURE METHODS, 2013, 10 (03) : 249 - 252
  • [19] DETECTION, ASSAY, AND PRELIMINARY PURIFICATION OF THE PIGMENT CONTROLLING PHOTORESPONSIVE DEVELOPMENT OF PLANTS
    BUTLER, WL
    NORRIS, KH
    SIEGELMAN, HW
    HENDRICKS, SB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1959, 45 (12) : 1703 - 1708
  • [20] Current concepts in cobalamin deficiency
    Carmel, R
    [J]. ANNUAL REVIEW OF MEDICINE, 2000, 51 : 357 - 375
12345678910