Ischaemic stroke - impact of renal dysfunction on in-hospital mortality

被引:41
|
作者
Fabjan, T. Hojs
Hojs, R.
Tetickovic, E.
Balon, B. Pecovnik
机构
[1] Univ Clin Ctr, Dept Neurol, Maribor, Slovenia
[2] Univ Clin Ctr, Dept Nephrol, Maribor, Slovenia
关键词
hospital mortality; ischaemic stroke; renal dysfunction; risk factors;
D O I
10.1111/j.1468-1331.2007.01976.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Renal dysfunction predicts mortality in patients with myocardial infarction but less is known about the impact of renal dysfunction on in-hospital mortality after ischaemic stroke. All 361 patients (185 men, 176 women; mean age 72.1 years) with ischaemic stroke and glomerular filtration rate (GFR) < 90 ml/min/1.73 m(2) were followed-up. GFR was calculated according to abbreviated modification of diet in renal disease (MDRD) formula. Stroke severity was determined by National Institutes of Health Stroke Scale (NIHSS). The mean GFR was 61.5 +/- 16.6 ml/min/1.73 m(2). There were 49 (13.6%) in-hospital deaths. Patients who died had higher NIHSS (P = 0.0001), were older (P = 0.024), had lower GFR (P = 0.028), higher hs-C-reactive protein (P = 0.001) and lower albumin (P = 0.048). No differences in presence of diabetes and hypertension, cholesterol (total, HDL and LDL), triglycerides and BMI between patients who died or survived were found. With univariate analysis association between in-hospital mortality and NIHSS (P = 0.0001), GFR (P = 0.041), total cholesterol (P = 0.021) and LDL cholesterol (P = 0.034) was found. With Cox multivariable regression analysis of risk factors, NIHSS (P = 0.0001), GFR (P = 0.018), total cholesterol (P = 0.008) and LDL cholesterol (P = 0.011) were only predictors of in-hospital mortality. In patients with ischaemic stroke, decreased GFR was associated with higher in-hospital mortality.
引用
收藏
页码:1351 / 1356
页数:6
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